Relatively low red cell folate levels and acute coronary syndromes
Φόρτωση...
Ημερομηνία
Συγγραφείς
Michalis, L. K.
Pappas, K.
Tweddel, A.
Kolaitis, N.
Katsouras, C. S.
Loukas, S.
Goudevenos, J.
Bourantas, K.
Sideris, D. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Lippincott, Williams & Wilkins
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Coron Artery Dis
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Background Low folate levels are related to increased risk for coronary artery disease in humans, while experimental work has shown that folate deficiency is thrombogenic. We hypothesized that relatively low folate levels are related to the development of acute coronary syndromes in patients with previously stable coronary artery disease. Methods One hundred and forty-one men were studied: 53 consecutive patients with acute coronary syndromes, 41 with stable coronary artery disease and 47 control participants. Known clinical and lipid risk factors were identified in all subjects and in addition plasma B-12, plasma and red cell folate levels were measured. Results Red cell folate levels were significantly lower in patients with acute coronary syndromes (510 +/- 178 nmol/l) than in both stable coronary artery disease patients (638 +/- 264 nmol/l, P<0.005) and controls (615<plus/minus>193nmol/l, P<0.05 respectively). Plasma folate and B-12 levels were similar in all three groups. Multiple logistic regression analysis identified red cell folate levels as the only independent predictor of acute coronary events in the whole population of patients with known coronary artery disease and in the subgroup of non-smokers (P=0.010 and P=0.031). Conclusions The present study suggests that relatively low red cell folate levels are associated with acute coronary syndromes and are an independent predictor of acute coronary events, Coron Artery Dis 12:665-668 (C) 2001 Lippincott Williams & Wilkins.
Περιγραφή
Λέξεις-κλειδιά
red cell folate, acute coronary syndromes, coronary artery disease, whole-blood folate, myocardial-infarction, artery disease, heart-disease, plasma homocysteine, vascular-disease, unstable angina, serum folate, risk-factors, atherosclerosis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000173023400010
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μαθηματικών