Relatively low red cell folate levels and acute coronary syndromes

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dc.contributor.authorMichalis, L. K.en
dc.contributor.authorPappas, K.en
dc.contributor.authorTweddel, A.en
dc.contributor.authorKolaitis, N.en
dc.contributor.authorKatsouras, C. S.en
dc.contributor.authorLoukas, S.en
dc.contributor.authorGoudevenos, J.en
dc.contributor.authorBourantas, K.en
dc.contributor.authorSideris, D. A.en
dc.date.accessioned2015-11-24T17:27:50Z
dc.date.available2015-11-24T17:27:50Z
dc.identifier.issn0954-6928-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/13456
dc.rightsDefault Licence-
dc.subjectred cell folateen
dc.subjectacute coronary syndromesen
dc.subjectcoronary artery diseaseen
dc.subjectwhole-blood folateen
dc.subjectmyocardial-infarctionen
dc.subjectartery diseaseen
dc.subjectheart-diseaseen
dc.subjectplasma homocysteineen
dc.subjectvascular-diseaseen
dc.subjectunstable anginaen
dc.subjectserum folateen
dc.subjectrisk-factorsen
dc.subjectatherosclerosisen
dc.titleRelatively low red cell folate levels and acute coronary syndromesen
heal.abstractBackground Low folate levels are related to increased risk for coronary artery disease in humans, while experimental work has shown that folate deficiency is thrombogenic. We hypothesized that relatively low folate levels are related to the development of acute coronary syndromes in patients with previously stable coronary artery disease. Methods One hundred and forty-one men were studied: 53 consecutive patients with acute coronary syndromes, 41 with stable coronary artery disease and 47 control participants. Known clinical and lipid risk factors were identified in all subjects and in addition plasma B-12, plasma and red cell folate levels were measured. Results Red cell folate levels were significantly lower in patients with acute coronary syndromes (510 +/- 178 nmol/l) than in both stable coronary artery disease patients (638 +/- 264 nmol/l, P<0.005) and controls (615<plus/minus>193nmol/l, P<0.05 respectively). Plasma folate and B-12 levels were similar in all three groups. Multiple logistic regression analysis identified red cell folate levels as the only independent predictor of acute coronary events in the whole population of patients with known coronary artery disease and in the subgroup of non-smokers (P=0.010 and P=0.031). Conclusions The present study suggests that relatively low red cell folate levels are associated with acute coronary syndromes and are an independent predictor of acute coronary events, Coron Artery Dis 12:665-668 (C) 2001 Lippincott Williams & Wilkins.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000173023400010-
heal.journalNameCoron Artery Disen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2001-
heal.publisherLippincott, Williams & Wilkinsen
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μαθηματικώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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