Increased risk of oral cancer in diabetic animals is not associated with c-jun activation pathway
Φόρτωση...
Ημερομηνία
Συγγραφείς
Vairaktaris, E.
Goutzanis, L.
Kalokerinos, G.
Vassiliou, S.
Spyridonidou, S.
Avgoustidis, D.
Strantzias, P.
Lazaris, A.
Papageorgiou, G.
Ragos, V.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Craniomaxillofac Surg
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
PURPOSE: The expression of oncogenic protein c-jun was investigated in an experimental model of chemically induced carcinogenesis in normal and diabetic (type I) Sprague-Dawley rats. MATERIAL AND METHODS: Thirteen diabetic and twelve normal rats developed cancer after 4-nitroquinoline-N-oxide treatment, while six diabetic and six normal animals were used as controls. The biopsies were classified pathologically from oral mucosal dysplasia to moderately differentiated oral squamous cell carcinoma (OSCC) and studied immunohistochemically using monoclonal antibody against c-jun protein. RESULTS: Higher c-jun levels were observed in non-cancerous and precancerous stages of normal rats compared with diabetic rats, while in different tumour stages, the expression of c-jun was practically identical for both groups. CONCLUSION: It seems that diabetes does not affect the c-jun N-terminal kinase (JNK)/c-jun pathway.
Περιγραφή
Λέξεις-κλειδιά
4-Nitroquinoline-1-oxide/adverse effects, Animals, Biopsy, Carcinogens, Carcinoma, Squamous Cell/chemically induced/genetics/pathology, Diabetes Mellitus, Experimental/*complications/genetics, Female, Gene Expression Regulation, Enzymologic/genetics, Gene Expression Regulation, Neoplastic/genetics, Immunohistochemistry, JNK Mitogen-Activated Protein Kinases/genetics, Mouth Mucosa/drug effects/pathology, Mouth Neoplasms/*chemically induced/genetics/pathology, Neoplasm Staging, Precancerous Conditions/chemically induced/genetics/pathology, Proto-Oncogene Proteins c-jun/*genetics, Random Allocation, Rats, Rats, Sprague-Dawley, Risk Factors
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18023197
http://ac.els-cdn.com/S1010518207000972/1-s2.0-S1010518207000972-main.pdf?_tid=35605916b2da45cd9d664b7a56d68146&acdnat=1332845835_cd46e99863b50db9a6ced7e83df6aebd
http://ac.els-cdn.com/S1010518207000972/1-s2.0-S1010518207000972-main.pdf?_tid=35605916b2da45cd9d664b7a56d68146&acdnat=1332845835_cd46e99863b50db9a6ced7e83df6aebd
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής