Increased risk of oral cancer in diabetic animals is not associated with c-jun activation pathway

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dc.contributor.authorVairaktaris, E.en
dc.contributor.authorGoutzanis, L.en
dc.contributor.authorKalokerinos, G.en
dc.contributor.authorVassiliou, S.en
dc.contributor.authorSpyridonidou, S.en
dc.contributor.authorAvgoustidis, D.en
dc.contributor.authorStrantzias, P.en
dc.contributor.authorLazaris, A.en
dc.contributor.authorPapageorgiou, G.en
dc.contributor.authorRagos, V.en
dc.contributor.authorYapijakis, C.en
dc.contributor.authorPatsouris, E.en
dc.date.accessioned2015-11-24T19:10:41Z
dc.date.available2015-11-24T19:10:41Z
dc.identifier.issn1010-5182-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20856
dc.rightsDefault Licence-
dc.subject4-Nitroquinoline-1-oxide/adverse effectsen
dc.subjectAnimalsen
dc.subjectBiopsyen
dc.subjectCarcinogensen
dc.subjectCarcinoma, Squamous Cell/chemically induced/genetics/pathologyen
dc.subjectDiabetes Mellitus, Experimental/*complications/geneticsen
dc.subjectFemaleen
dc.subjectGene Expression Regulation, Enzymologic/geneticsen
dc.subjectGene Expression Regulation, Neoplastic/geneticsen
dc.subjectImmunohistochemistryen
dc.subjectJNK Mitogen-Activated Protein Kinases/geneticsen
dc.subjectMouth Mucosa/drug effects/pathologyen
dc.subjectMouth Neoplasms/*chemically induced/genetics/pathologyen
dc.subjectNeoplasm Stagingen
dc.subjectPrecancerous Conditions/chemically induced/genetics/pathologyen
dc.subjectProto-Oncogene Proteins c-jun/*geneticsen
dc.subjectRandom Allocationen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectRisk Factorsen
dc.titleIncreased risk of oral cancer in diabetic animals is not associated with c-jun activation pathwayen
heal.abstractPURPOSE: The expression of oncogenic protein c-jun was investigated in an experimental model of chemically induced carcinogenesis in normal and diabetic (type I) Sprague-Dawley rats. MATERIAL AND METHODS: Thirteen diabetic and twelve normal rats developed cancer after 4-nitroquinoline-N-oxide treatment, while six diabetic and six normal animals were used as controls. The biopsies were classified pathologically from oral mucosal dysplasia to moderately differentiated oral squamous cell carcinoma (OSCC) and studied immunohistochemically using monoclonal antibody against c-jun protein. RESULTS: Higher c-jun levels were observed in non-cancerous and precancerous stages of normal rats compared with diabetic rats, while in different tumour stages, the expression of c-jun was practically identical for both groups. CONCLUSION: It seems that diabetes does not affect the c-jun N-terminal kinase (JNK)/c-jun pathway.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.jcms.2007.05.006-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18023197-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1010518207000972/1-s2.0-S1010518207000972-main.pdf?_tid=35605916b2da45cd9d664b7a56d68146&acdnat=1332845835_cd46e99863b50db9a6ced7e83df6aebd-
heal.journalNameJ Craniomaxillofac Surgen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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