Tracking changes of lymphocyte subsets and pre-inflammatory mediators in full-term neonates with suspected or documented infection
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Ημερομηνία
Συγγραφείς
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Scand J Immunol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Investigation was made of changes in immune system parameters during the course of neonatal infection. The study population consisted of 95 full-term neonates matched for chronological age and sex, divided into three groups: suspected infection (n=20), sepsis (n=25), infection-free control subjects (n=50). Serial measurements were made of the cytokines interleukin-6 (IL-6), interleukin-1b (IL-1b) and tumour necrosis factor-alpha (TNF-alpha), lymphocyte subsets [CD3+, CD4+, CD8+, natural killer (NK) cells and B cells], the immunoglobulins (Ig) (IgG, IgM and IgA), C-reactive protein (CRP), and the total blood count, before, 2 days after initiation of treatment and after stopping treatment (time periods first, second and third, respectively). IL6, TNF-alpha, IL1-b and CRP were higher at the first time period in the sepsis group, and IL6 and TNF-alpha continued to be higher in this group at the second period. IL-6 and TNF-alpha were precise sepsis predictors with sensitivity and specificity of 0.92, 0.98 and 0.91, 0.92, respectively. NK cells, B cells, CD3+, CD4+, CD8+ were higher in the sepsis and suspected infection groups, but the ratios CD3+/CD4+, CD3+/CD8+, CD4+/CD8+ showed no difference from the controls. IgG was lower and IgM higher in the sepsis group. In the control subjects CD3+, CD4+, CD8+ lymphocytes increased with increasing age. It is concluded that IL-6 and TNF are good diagnostic markers of sepsis in full-term neonates. Lymphocyte subsets were affected by both the clinical condition and the chronological age. NK and B cells may be elevated in suspected and documented sepsis, and further studies are needed to determine their clinical significance.
Περιγραφή
Λέξεις-κλειδιά
Bacterial Infections/blood/diagnosis/*immunology, Biological Markers/*blood, C-Reactive Protein/metabolism, Enzyme-Linked Immunosorbent Assay, Female, Humans, Infant, Newborn, Inflammation Mediators/*blood/immunology, Interleukin-1/blood, Interleukin-6/blood, Lymphocyte Subsets/*immunology, Male, Sensitivity and Specificity, Sepsis/blood/diagnosis/*immunology, Tumor Necrosis Factor-alpha/blood
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21204898
http://onlinelibrary.wiley.com/store/10.1111/j.1365-3083.2010.02499.x/asset/j.1365-3083.2010.02499.x.pdf?v=1&t=h0cay6s5&s=dd9227dd80af6a0418fbe614fc1d9b1e46739a88
http://onlinelibrary.wiley.com/store/10.1111/j.1365-3083.2010.02499.x/asset/j.1365-3083.2010.02499.x.pdf?v=1&t=h0cay6s5&s=dd9227dd80af6a0418fbe614fc1d9b1e46739a88
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής