Tracking changes of lymphocyte subsets and pre-inflammatory mediators in full-term neonates with suspected or documented infection
Φόρτωση...
Ημερομηνία
Συγγραφείς
Hotoura, E.
Giapros, V.
Kostoula, A.
Spirou, P.
Andronikou, S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Scand J Immunol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Investigation was made of changes in immune system parameters during the course of neonatal infection. The study population consisted of 95 full-term neonates matched for chronological age and sex, divided into three groups: suspected infection (n=20), sepsis (n=25), infection-free control subjects (n=50). Serial measurements were made of the cytokines interleukin-6 (IL-6), interleukin-1b (IL-1b) and tumour necrosis factor-alpha (TNF-alpha), lymphocyte subsets [CD3+, CD4+, CD8+, natural killer (NK) cells and B cells], the immunoglobulins (Ig) (IgG, IgM and IgA), C-reactive protein (CRP), and the total blood count, before, 2 days after initiation of treatment and after stopping treatment (time periods first, second and third, respectively). IL6, TNF-alpha, IL1-b and CRP were higher at the first time period in the sepsis group, and IL6 and TNF-alpha continued to be higher in this group at the second period. IL-6 and TNF-alpha were precise sepsis predictors with sensitivity and specificity of 0.92, 0.98 and 0.91, 0.92, respectively. NK cells, B cells, CD3+, CD4+, CD8+ were higher in the sepsis and suspected infection groups, but the ratios CD3+/CD4+, CD3+/CD8+, CD4+/CD8+ showed no difference from the controls. IgG was lower and IgM higher in the sepsis group. In the control subjects CD3+, CD4+, CD8+ lymphocytes increased with increasing age. It is concluded that IL-6 and TNF are good diagnostic markers of sepsis in full-term neonates. Lymphocyte subsets were affected by both the clinical condition and the chronological age. NK and B cells may be elevated in suspected and documented sepsis, and further studies are needed to determine their clinical significance.
Περιγραφή
Λέξεις-κλειδιά
Bacterial Infections/blood/diagnosis/*immunology, Biological Markers/*blood, C-Reactive Protein/metabolism, Enzyme-Linked Immunosorbent Assay, Female, Humans, Infant, Newborn, Inflammation Mediators/*blood/immunology, Interleukin-1/blood, Interleukin-6/blood, Lymphocyte Subsets/*immunology, Male, Sensitivity and Specificity, Sepsis/blood/diagnosis/*immunology, Tumor Necrosis Factor-alpha/blood
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21204898
http://onlinelibrary.wiley.com/store/10.1111/j.1365-3083.2010.02499.x/asset/j.1365-3083.2010.02499.x.pdf?v=1&t=h0cay6s5&s=dd9227dd80af6a0418fbe614fc1d9b1e46739a88
http://onlinelibrary.wiley.com/store/10.1111/j.1365-3083.2010.02499.x/asset/j.1365-3083.2010.02499.x.pdf?v=1&t=h0cay6s5&s=dd9227dd80af6a0418fbe614fc1d9b1e46739a88
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής