Tracking changes of lymphocyte subsets and pre-inflammatory mediators in full-term neonates with suspected or documented infection

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dc.contributor.authorHotoura, E.en
dc.contributor.authorGiapros, V.en
dc.contributor.authorKostoula, A.en
dc.contributor.authorSpirou, P.en
dc.contributor.authorAndronikou, S.en
dc.date.accessioned2015-11-24T19:12:06Z
dc.date.available2015-11-24T19:12:06Z
dc.identifier.issn1365-3083-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21020
dc.rightsDefault Licence-
dc.subjectBacterial Infections/blood/diagnosis/*immunologyen
dc.subjectBiological Markers/*blooden
dc.subjectC-Reactive Protein/metabolismen
dc.subjectEnzyme-Linked Immunosorbent Assayen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInfant, Newbornen
dc.subjectInflammation Mediators/*blood/immunologyen
dc.subjectInterleukin-1/blooden
dc.subjectInterleukin-6/blooden
dc.subjectLymphocyte Subsets/*immunologyen
dc.subjectMaleen
dc.subjectSensitivity and Specificityen
dc.subjectSepsis/blood/diagnosis/*immunologyen
dc.subjectTumor Necrosis Factor-alpha/blooden
dc.titleTracking changes of lymphocyte subsets and pre-inflammatory mediators in full-term neonates with suspected or documented infectionen
heal.abstractInvestigation was made of changes in immune system parameters during the course of neonatal infection. The study population consisted of 95 full-term neonates matched for chronological age and sex, divided into three groups: suspected infection (n=20), sepsis (n=25), infection-free control subjects (n=50). Serial measurements were made of the cytokines interleukin-6 (IL-6), interleukin-1b (IL-1b) and tumour necrosis factor-alpha (TNF-alpha), lymphocyte subsets [CD3+, CD4+, CD8+, natural killer (NK) cells and B cells], the immunoglobulins (Ig) (IgG, IgM and IgA), C-reactive protein (CRP), and the total blood count, before, 2 days after initiation of treatment and after stopping treatment (time periods first, second and third, respectively). IL6, TNF-alpha, IL1-b and CRP were higher at the first time period in the sepsis group, and IL6 and TNF-alpha continued to be higher in this group at the second period. IL-6 and TNF-alpha were precise sepsis predictors with sensitivity and specificity of 0.92, 0.98 and 0.91, 0.92, respectively. NK cells, B cells, CD3+, CD4+, CD8+ were higher in the sepsis and suspected infection groups, but the ratios CD3+/CD4+, CD3+/CD8+, CD4+/CD8+ showed no difference from the controls. IgG was lower and IgM higher in the sepsis group. In the control subjects CD3+, CD4+, CD8+ lymphocytes increased with increasing age. It is concluded that IL-6 and TNF are good diagnostic markers of sepsis in full-term neonates. Lymphocyte subsets were affected by both the clinical condition and the chronological age. NK and B cells may be elevated in suspected and documented sepsis, and further studies are needed to determine their clinical significance.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1365-3083.2010.02499.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21204898-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1365-3083.2010.02499.x/asset/j.1365-3083.2010.02499.x.pdf?v=1&t=h0cay6s5&s=dd9227dd80af6a0418fbe614fc1d9b1e46739a88-
heal.journalNameScand J Immunolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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