Synthesis, characterization, and DNA-binding studies of nitro(oligopyridine) ruthenium(II) complexes
Φόρτωση...
Ημερομηνία
Συγγραφείς
Karidi, K.
Garoufis, A.
Hadjiliadis, N.
Lutz, M.
Spek, A. L.
Reedijk, J.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
American Chemical Society
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Inorg Chem
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The complexes of general formulas [Ru-II(terpy)(4-CO2H-4'-Mebpy)(X)](n+) (X = NO (n = 3) and NO2 (n = 1); 1, 2) and [Ru-II(terpy)(4-COGHK-4'-Mebpy)(X)] (X = NO (n = 3) and NO2 (n = 1); 3, 4) were synthesized and characterized. The complex [Ru-II(terpy)(4-CO2-4'-Mebpy)(NO2)](-)7.5H(2)O has also been characterized by X-ray crystallographic studies. It crystallizes in the triclinic system: a = 9.4982(1) angstrom, b = 13.1330(1) angstrom, c = 14.2498(2) angstrom; alpha = 110.5870(6)xbc, beta = 98.4048(5)xbc, gamma = 106.4353(5), P (1) over bar, Z = 2. The crystal structure reveals an extended hydrogen-bonding network. Two water molecules form strong hydrogen bonds with the nitro and the carboxylic oxygen atoms of two separate units of the complex, resulting in a dimeric unit. The dimers are bridged by a (H2O)(15) cluster, consisting of two cyclo-(H2O)(6) species, while an exo-H2O(8) connects them. Two more exo-H2O molecules are joined together and connect the cyclo-(H2O)(6) units with the H2O(1) of the dimeric unit. It was found that complexes 1 and 3 can be transformed into their nitro derivatives in aqueous media at neutral pH. Photorelease of NO in dry MeCN solutions was observed for complexes 1 and 3. Also, complex 2 partially releases (NO2)(-) in MeCN upon visible light irradiation. Complex 2 interacts with short fragments (70-300 bp) of calf thymus DNA shortening slightly the apparent polynucleotide length, while the conjugation of the peptide GHK to it (2) affects its DNA-binding mode. The peptide moiety of complex 4 was found to interact with the DNA helix in a synergistic way with the whole complex. Preliminary results of photocleavage of DNA by complex 2 are also reported.
Περιγραφή
Λέξεις-κλειδιά
calf thymus DNA, crystal-structure, nitric-oxide, deoxynucleotide duplex, nitrosyl complexes, electron-transfer, polypyridine complexes, stereospecific binding, circular-dichroism, ancillary ligands
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000242479700049
http://pubs.acs.org/doi/pdfplus/10.1021/ic0608039
http://pubs.acs.org/doi/pdfplus/10.1021/ic0608039
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας