Synthesis, characterization, and DNA-binding studies of nitro(oligopyridine) ruthenium(II) complexes
| dc.contributor.author | Karidi, K. | en |
| dc.contributor.author | Garoufis, A. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.contributor.author | Lutz, M. | en |
| dc.contributor.author | Spek, A. L. | en |
| dc.contributor.author | Reedijk, J. | en |
| dc.date.accessioned | 2015-11-24T16:49:31Z | |
| dc.date.available | 2015-11-24T16:49:31Z | |
| dc.identifier.issn | 0020-1669 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9496 | |
| dc.rights | Default Licence | - |
| dc.subject | calf thymus DNA | en |
| dc.subject | crystal-structure | en |
| dc.subject | nitric-oxide | en |
| dc.subject | deoxynucleotide duplex | en |
| dc.subject | nitrosyl complexes | en |
| dc.subject | electron-transfer | en |
| dc.subject | polypyridine complexes | en |
| dc.subject | stereospecific binding | en |
| dc.subject | circular-dichroism | en |
| dc.subject | ancillary ligands | en |
| dc.title | Synthesis, characterization, and DNA-binding studies of nitro(oligopyridine) ruthenium(II) complexes | en |
| heal.abstract | The complexes of general formulas [Ru-II(terpy)(4-CO2H-4'-Mebpy)(X)](n+) (X = NO (n = 3) and NO2 (n = 1); 1, 2) and [Ru-II(terpy)(4-COGHK-4'-Mebpy)(X)] (X = NO (n = 3) and NO2 (n = 1); 3, 4) were synthesized and characterized. The complex [Ru-II(terpy)(4-CO2-4'-Mebpy)(NO2)](-)7.5H(2)O has also been characterized by X-ray crystallographic studies. It crystallizes in the triclinic system: a = 9.4982(1) angstrom, b = 13.1330(1) angstrom, c = 14.2498(2) angstrom; alpha = 110.5870(6)xbc, beta = 98.4048(5)xbc, gamma = 106.4353(5), P (1) over bar, Z = 2. The crystal structure reveals an extended hydrogen-bonding network. Two water molecules form strong hydrogen bonds with the nitro and the carboxylic oxygen atoms of two separate units of the complex, resulting in a dimeric unit. The dimers are bridged by a (H2O)(15) cluster, consisting of two cyclo-(H2O)(6) species, while an exo-H2O(8) connects them. Two more exo-H2O molecules are joined together and connect the cyclo-(H2O)(6) units with the H2O(1) of the dimeric unit. It was found that complexes 1 and 3 can be transformed into their nitro derivatives in aqueous media at neutral pH. Photorelease of NO in dry MeCN solutions was observed for complexes 1 and 3. Also, complex 2 partially releases (NO2)(-) in MeCN upon visible light irradiation. Complex 2 interacts with short fragments (70-300 bp) of calf thymus DNA shortening slightly the apparent polynucleotide length, while the conjugation of the peptide GHK to it (2) affects its DNA-binding mode. The peptide moiety of complex 4 was found to interact with the DNA helix in a synergistic way with the whole complex. Preliminary results of photocleavage of DNA by complex 2 are also reported. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | Doi 10.1021/Ic0608039 | - |
| heal.identifier.secondary | <Go to ISI>://000242479700049 | - |
| heal.identifier.secondary | http://pubs.acs.org/doi/pdfplus/10.1021/ic0608039 | - |
| heal.journalName | Inorg Chem | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2006 | - |
| heal.publisher | American Chemical Society | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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