Metabolic syndrome and its components as predictors of all-cause mortality and coronary heart disease in type 2 diabetic patients
Φόρτωση...
Ημερομηνία
Συγγραφείς
Protopsaltis, I.
Nikolopoulos, G.
Dimou, E.
Brestas, P.
Kokkoris, S.
Korantzopoulos, P.
Melidonis, A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Atherosclerosis
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: There is no consistent evidence regarding the prognostic value of metabolic syndrome (MS) in predicting all-cause mortality and coronary heart disease (CHD) risk among type 2 diabetic patients. We sought to investigate whether individual or various combinations of MS components have a different predictive value than the presence of MS in this setting. METHODS: Six hundred type 2 diabetic patients (mean age 60.4+/-9 years, 54% males) without known CHD were prospectively followed-up for a mean period of 10.06 years. The presence of MS was examined using the National Cholesterol Education Program (NCEP) definition. Statistical analyses were performed using Kaplan-Meier estimator and Cox proportional Hazard models. RESULTS: MS was present in 62.4% of the patients while 142 died during follow-up. Significant predictors for all-cause mortality were the presence of MS (HR 1.75), sex (HR 1.69), age (HR 1.09), and diabetes duration (HR 1.02). Regarding CHD incidents, HDL (HR 0.98), systolic blood pressure (HR 1.01), sex (HR 2.05), and total cholesterol (HR 1.005) were significant predictors while the presence of MS was not. Subjects fulfilling the triad consisting of diabetes, hypertension, and low HDL or the combination of diabetes, hypertension, low HDL, and high triglyceride levels had the highest probability for developing CHD events (HR 1.79, 1.73, respectively). CONCLUSIONS: The presence of MS in type 2 diabetic patients without known CHD reduces the 10-year survival while specific combinations of its components have different impact on CHD risk.
Περιγραφή
Λέξεις-κλειδιά
Aged, Coronary Disease/*complications/mortality, Diabetes Mellitus/metabolism, Diabetes Mellitus, Type 2/*complications/mortality, Female, Humans, Male, Metabolic Syndrome X/*complications/mortality, Middle Aged, Predictive Value of Tests, Prognosis, Risk, Time Factors, Treatment Outcome
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17064711
http://ac.els-cdn.com/S0021915006005910/1-s2.0-S0021915006005910-main.pdf?_tid=2602551c06dd589b57d88353362cf19f&acdnat=1333965354_c96546c2f43b26a62b05064b8258076a
http://ac.els-cdn.com/S0021915006005910/1-s2.0-S0021915006005910-main.pdf?_tid=2602551c06dd589b57d88353362cf19f&acdnat=1333965354_c96546c2f43b26a62b05064b8258076a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής