Metabolic syndrome and its components as predictors of all-cause mortality and coronary heart disease in type 2 diabetic patients

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dc.contributor.authorProtopsaltis, I.en
dc.contributor.authorNikolopoulos, G.en
dc.contributor.authorDimou, E.en
dc.contributor.authorBrestas, P.en
dc.contributor.authorKokkoris, S.en
dc.contributor.authorKorantzopoulos, P.en
dc.contributor.authorMelidonis, A.en
dc.date.accessioned2015-11-24T19:04:36Z
dc.date.available2015-11-24T19:04:36Z
dc.identifier.issn1879-1484-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20071
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectCoronary Disease/*complications/mortalityen
dc.subjectDiabetes Mellitus/metabolismen
dc.subjectDiabetes Mellitus, Type 2/*complications/mortalityen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMetabolic Syndrome X/*complications/mortalityen
dc.subjectMiddle Ageden
dc.subjectPredictive Value of Testsen
dc.subjectPrognosisen
dc.subjectRisken
dc.subjectTime Factorsen
dc.subjectTreatment Outcomeen
dc.titleMetabolic syndrome and its components as predictors of all-cause mortality and coronary heart disease in type 2 diabetic patientsen
heal.abstractBACKGROUND: There is no consistent evidence regarding the prognostic value of metabolic syndrome (MS) in predicting all-cause mortality and coronary heart disease (CHD) risk among type 2 diabetic patients. We sought to investigate whether individual or various combinations of MS components have a different predictive value than the presence of MS in this setting. METHODS: Six hundred type 2 diabetic patients (mean age 60.4+/-9 years, 54% males) without known CHD were prospectively followed-up for a mean period of 10.06 years. The presence of MS was examined using the National Cholesterol Education Program (NCEP) definition. Statistical analyses were performed using Kaplan-Meier estimator and Cox proportional Hazard models. RESULTS: MS was present in 62.4% of the patients while 142 died during follow-up. Significant predictors for all-cause mortality were the presence of MS (HR 1.75), sex (HR 1.69), age (HR 1.09), and diabetes duration (HR 1.02). Regarding CHD incidents, HDL (HR 0.98), systolic blood pressure (HR 1.01), sex (HR 2.05), and total cholesterol (HR 1.005) were significant predictors while the presence of MS was not. Subjects fulfilling the triad consisting of diabetes, hypertension, and low HDL or the combination of diabetes, hypertension, low HDL, and high triglyceride levels had the highest probability for developing CHD events (HR 1.79, 1.73, respectively). CONCLUSIONS: The presence of MS in type 2 diabetic patients without known CHD reduces the 10-year survival while specific combinations of its components have different impact on CHD risk.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.atherosclerosis.2006.09.019-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17064711-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0021915006005910/1-s2.0-S0021915006005910-main.pdf?_tid=2602551c06dd589b57d88353362cf19f&acdnat=1333965354_c96546c2f43b26a62b05064b8258076a-
heal.journalNameAtherosclerosisen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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