Apoptosis and adenocarcinoma of the cardia: expression of p53, Bcl-2, Bcl-XL, WAF1, and fas proteins and association with characteristics of the tumors
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Vlachos, K.
Siafakas, N.
Karameris, A.
Athanasas, G.
Theodoropoulos, G.
Peros, G.
Papadopoulos, J.
Hakim, N.
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peer-reviewed
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Int Surg
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Our knowledge regarding the biology of the gastroesophageal junction adenocarcinomas is still incomplete. Paraffin-embedded sections from 31 surgically resected primary cardia adenocarcinomas were examined by immunohistochemistry. Statistical analysis showed that Bcl-2 expression was significantly correlated with the age of the patients (P = 0.043), whereas Bcl-X(L) expression was inversely correlated with Bcl-2 expression (P = 0.021). An inverse correlation of high statistical significance was also found between p53 and Bcl-2 expression (P = 0.000). Fas expression was highly correlated with tumor stage (P = 0.006), degree of differentiation (P = 0.044), and the stage of the disease (P = 0.029). A significant correlation was also observed between the expression levels of WAF1 and Fas (P = 0.037), Fas and Bcl-X(L) (P = 0.018), and WAF1 and p53 (P = 0.018). These proteins may contribute to the estimation of the properties of adenocarcinomas of the gastroesophageal junction, facilitating prognosis of cancer patients treated by multimode therapy.
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Adenocarcinoma/*metabolism, Age Factors, Analysis of Variance, Antigens, CD95/*metabolism, Apoptosis, Cardia/metabolism/*pathology, Chi-Square Distribution, Cyclin-Dependent Kinase Inhibitor p21/*metabolism, Esophagogastric Junction/*pathology, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Proto-Oncogene Proteins c-bcl-2/metabolism, Tumor Markers, Biological/metabolism, Tumor Suppressor Protein p53/*metabolism, bcl-X Protein/*metabolism
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http://www.ncbi.nlm.nih.gov/pubmed/18828269
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής