Apoptosis and adenocarcinoma of the cardia: expression of p53, Bcl-2, Bcl-XL, WAF1, and fas proteins and association with characteristics of the tumors

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dc.contributor.authorVlachos, K.en
dc.contributor.authorSiafakas, N.en
dc.contributor.authorKarameris, A.en
dc.contributor.authorAthanasas, G.en
dc.contributor.authorTheodoropoulos, G.en
dc.contributor.authorPeros, G.en
dc.contributor.authorPapadopoulos, J.en
dc.contributor.authorHakim, N.en
dc.date.accessioned2015-11-24T19:35:48Z
dc.date.available2015-11-24T19:35:48Z
dc.identifier.issn0020-8868-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23749
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/*metabolismen
dc.subjectAge Factorsen
dc.subjectAnalysis of Varianceen
dc.subjectAntigens, CD95/*metabolismen
dc.subjectApoptosisen
dc.subjectCardia/metabolism/*pathologyen
dc.subjectChi-Square Distributionen
dc.subjectCyclin-Dependent Kinase Inhibitor p21/*metabolismen
dc.subjectEsophagogastric Junction/*pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectProto-Oncogene Proteins c-bcl-2/metabolismen
dc.subjectTumor Markers, Biological/metabolismen
dc.subjectTumor Suppressor Protein p53/*metabolismen
dc.subjectbcl-X Protein/*metabolismen
dc.titleApoptosis and adenocarcinoma of the cardia: expression of p53, Bcl-2, Bcl-XL, WAF1, and fas proteins and association with characteristics of the tumorsen
heal.abstractOur knowledge regarding the biology of the gastroesophageal junction adenocarcinomas is still incomplete. Paraffin-embedded sections from 31 surgically resected primary cardia adenocarcinomas were examined by immunohistochemistry. Statistical analysis showed that Bcl-2 expression was significantly correlated with the age of the patients (P = 0.043), whereas Bcl-X(L) expression was inversely correlated with Bcl-2 expression (P = 0.021). An inverse correlation of high statistical significance was also found between p53 and Bcl-2 expression (P = 0.000). Fas expression was highly correlated with tumor stage (P = 0.006), degree of differentiation (P = 0.044), and the stage of the disease (P = 0.029). A significant correlation was also observed between the expression levels of WAF1 and Fas (P = 0.037), Fas and Bcl-X(L) (P = 0.018), and WAF1 and p53 (P = 0.018). These proteins may contribute to the estimation of the properties of adenocarcinomas of the gastroesophageal junction, facilitating prognosis of cancer patients treated by multimode therapy.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18828269-
heal.journalNameInt Surgen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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