Prevalence of inflammatory bowel disease related dysplasia and cancer in 1500 colonoscopies from a referral center in northwestern Greece

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dc.contributor.authorKatsanos, K. H.en
dc.contributor.authorStamou, P.en
dc.contributor.authorTatsioni, A.en
dc.contributor.authorTsianos, V. E.en
dc.contributor.authorZoumbas, S.en
dc.contributor.authorKavvadia, S.en
dc.contributor.authorGiga, A.en
dc.contributor.authorVagias, I.en
dc.contributor.authorChristodoulou, D. K.en
dc.contributor.authorTsianos, E. V.en
dc.date.accessioned2015-11-24T18:56:50Z
dc.date.available2015-11-24T18:56:50Z
dc.identifier.issn1876-4479-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19100
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectColitis, Ulcerative/complicationsen
dc.subjectColonoscopy/statistics & numerical dataen
dc.subjectCrohn Disease/complicationsen
dc.subjectGreece/epidemiologyen
dc.subjectHumansen
dc.subjectInflammatory Bowel Diseases/*complicationsen
dc.subjectIntestinal Diseases/*complications/epidemiologyen
dc.subjectIntestinal Neoplasms/*complications/epidemiologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPrevalenceen
dc.subjectRetrospective Studiesen
dc.subjectRisk Factorsen
dc.subjectYoung Adulten
dc.titlePrevalence of inflammatory bowel disease related dysplasia and cancer in 1500 colonoscopies from a referral center in northwestern Greeceen
heal.abstractBACKGROUND AND AIM: To report on the prevalence of inflammatory bowel disease (IBD) related intestinal dysplasia and cancer in northwestern Greece. PATIENTS AND METHODS: Single referral center retrospective study. The policy among all gastroenterologists of the area regarding medical treatment, patient follow up and bowel surveillance strategies including risk factors is the same. RESULTS: We analyzed 1494 colonoscopies from 696 consecutive IBD patients (494 UC). The follow up time [median, IQR] was 16 [8-23] years and the age at diagnosis was 28 [21-49] years. The number of patient years at risk was 16.219. Disease location for UC was: pancolitis 761 (59%), left sided colitis 455 (35%), and proctitis 69 (6%). Disease location for CD was: colitis 142 (66%), ileitis 45 (22%) and ileocolitis 21 (10%). Disease activity was in remission in 1240 (83%) of them. In total, 498 (72%) patients were on mesalazine, 169(24%) on immunosuppression and 29 (4%) on biologicals. Biopsies were taken randomly in 1429 (96%) endoscopies and were targeted in 65 (4%) of them. We recorded 69 (9.4%) cases with dysplasia and 10 (1.4%) cases with intestinal cancer (9 in UC). No difference was found for dysplasia and cancer in patients who followed up for 10-20 years or for more than 20 years. CONCLUSIONS: The prevalence of dysplasia and cancer is increased in UC compared to CD but the prevalence of high-grade dysplasia is comparatively low. Intestinal cancer prevalence is increasing after the first decade and then practically remains stable.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.crohns.2010.09.001-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21272799-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1873994610001613/1-s2.0-S1873994610001613-main.pdf?_tid=98d58dd3e26e9f3f6a7ddaf3de6d7321&acdnat=1333962255_50afba59d0c981a0c77789266982d8a5-
heal.journalNameJ Crohns Colitisen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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