Prolonged administration of erythropoietin increases erythroid response rate in myelodysplastic syndromes: a phase II trial in 281 patients
Φόρτωση...
Ημερομηνία
Συγγραφείς
Terpos, E.
Mougiou, A.
Kouraklis, A.
Chatzivassili, A.
Michalis, E.
Giannakoulas, N.
Manioudaki, E.
Lazaridou, A.
Bakaloudi, V.
Protopappa, M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Br J Haematol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Treatment with recombinant human erythropoietin (rHuEpo) improves anaemia in approximately 20% of patients with myelodysplastic syndromes (MDS). We investigated the potential advantage of a prolonged administration of rHuEpo to achieve higher erythroid response rates (RR) in 281 MDS patients: 118 with refractory anaemia (RA), 77 with refractory anaemia and ringed sideroblasts (RARS), 59 with refractory anaemia with excess of blasts and blast count < 10% (RAEB-I), and 27 with RAEB and blast count between 11-20% (RAEB-II). rHuEpo was given subcutaneously at a dose of 150 U/kg thrice weekly, for a minimum of 26 weeks. Response to treatment was evaluated after 12 and 26 weeks of therapy. The overall RR was 45.1%; the RR for RA, RARS, RAEB-I and RAEB-II were 48.3%, 58.4%, 33.8% and 13% respectively. A significant increase in RR was observed at week 26 in RA, RARS and RAEB-I patients, as the response probability increased with treatment duration. The RR was higher in the good cytogenetic prognostic group and serum Epo level of > 150 U/l at baseline predicted for non-response. The median duration of response was 68 weeks and the overall risk of leukaemic transformation was 21.7%. These results suggest that prolonged administration of rHuEpo produces high and long-lasting erythroid RR in MDS patients with low blast counts, particularly in those with pretreatment serum Epo levels of < 150 U/l and good cytogenetic prognosis.
Περιγραφή
Λέξεις-κλειδιά
Aged, Aged, 80 and over, Anemia, Refractory/drug therapy, Anemia, Refractory, with Excess of Blasts/drug therapy, Anemia, Sideroblastic/drug therapy, Erythropoietin/*therapeutic use, Female, Humans, Male, Middle Aged, Myelodysplastic Syndromes/*drug therapy, Prospective Studies, Treatment Outcome
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/12100145
http://onlinelibrary.wiley.com/store/10.1046/j.1365-2141.2002.03583.x/asset/j.1365-2141.2002.03583.x.pdf?v=1&t=h2bovhm4&s=51979d8006fc82b691e365af91a69cf80b1f323d
http://onlinelibrary.wiley.com/store/10.1046/j.1365-2141.2002.03583.x/asset/j.1365-2141.2002.03583.x.pdf?v=1&t=h2bovhm4&s=51979d8006fc82b691e365af91a69cf80b1f323d
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής