Prolonged administration of erythropoietin increases erythroid response rate in myelodysplastic syndromes: a phase II trial in 281 patients

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dc.contributor.authorTerpos, E.en
dc.contributor.authorMougiou, A.en
dc.contributor.authorKouraklis, A.en
dc.contributor.authorChatzivassili, A.en
dc.contributor.authorMichalis, E.en
dc.contributor.authorGiannakoulas, N.en
dc.contributor.authorManioudaki, E.en
dc.contributor.authorLazaridou, A.en
dc.contributor.authorBakaloudi, V.en
dc.contributor.authorProtopappa, M.en
dc.contributor.authorLiapi, D.en
dc.contributor.authorGrouzi, E.en
dc.contributor.authorParharidou, A.en
dc.contributor.authorSymeonidis, A.en
dc.contributor.authorKokkini, G.en
dc.contributor.authorLaoutaris, N. P.en
dc.contributor.authorVaipoulos, G.en
dc.contributor.authorAnagnostopoulos, N. I.en
dc.contributor.authorChristakis, J. I.en
dc.contributor.authorMeletis, J.en
dc.contributor.authorBourantas, K. L.en
dc.contributor.authorZoumbos, N. C.en
dc.contributor.authorYataganas, X.en
dc.contributor.authorViniou, N. A.en
dc.date.accessioned2015-11-24T18:56:08Z
dc.date.available2015-11-24T18:56:08Z
dc.identifier.issn0007-1048-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18988
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAnemia, Refractory/drug therapyen
dc.subjectAnemia, Refractory, with Excess of Blasts/drug therapyen
dc.subjectAnemia, Sideroblastic/drug therapyen
dc.subjectErythropoietin/*therapeutic useen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyelodysplastic Syndromes/*drug therapyen
dc.subjectProspective Studiesen
dc.subjectTreatment Outcomeen
dc.titleProlonged administration of erythropoietin increases erythroid response rate in myelodysplastic syndromes: a phase II trial in 281 patientsen
heal.abstractTreatment with recombinant human erythropoietin (rHuEpo) improves anaemia in approximately 20% of patients with myelodysplastic syndromes (MDS). We investigated the potential advantage of a prolonged administration of rHuEpo to achieve higher erythroid response rates (RR) in 281 MDS patients: 118 with refractory anaemia (RA), 77 with refractory anaemia and ringed sideroblasts (RARS), 59 with refractory anaemia with excess of blasts and blast count < 10% (RAEB-I), and 27 with RAEB and blast count between 11-20% (RAEB-II). rHuEpo was given subcutaneously at a dose of 150 U/kg thrice weekly, for a minimum of 26 weeks. Response to treatment was evaluated after 12 and 26 weeks of therapy. The overall RR was 45.1%; the RR for RA, RARS, RAEB-I and RAEB-II were 48.3%, 58.4%, 33.8% and 13% respectively. A significant increase in RR was observed at week 26 in RA, RARS and RAEB-I patients, as the response probability increased with treatment duration. The RR was higher in the good cytogenetic prognostic group and serum Epo level of > 150 U/l at baseline predicted for non-response. The median duration of response was 68 weeks and the overall risk of leukaemic transformation was 21.7%. These results suggest that prolonged administration of rHuEpo produces high and long-lasting erythroid RR in MDS patients with low blast counts, particularly in those with pretreatment serum Epo levels of < 150 U/l and good cytogenetic prognosis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12100145-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1046/j.1365-2141.2002.03583.x/asset/j.1365-2141.2002.03583.x.pdf?v=1&t=h2bovhm4&s=51979d8006fc82b691e365af91a69cf80b1f323d-
heal.journalNameBr J Haematolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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