Estrogens influence behavioral responses in a kainic acid model of neurotoxicity
Φόρτωση...
Ημερομηνία
Συγγραφείς
Papalexi, E.
Antoniou, K.
Kitraki, E.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Horm Behav
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The behavioral and neuroprotective effects of 17beta-estradiol (E2), on ovariectomized rats treated with a subconvulsive dose (7 mg/kg bw, ip) of kainic acid (KA), were examined. Estradiol was administered either acutely (150 mug/rat, ip) along with KA, 14 days post-ovariectomy, or chronically (sc capsules providing proestrus estrogen levels in serum) starting at ovariectomy. Exploratory behavior, as deduced by sniffing in the open field test, was reduced in KA-treated rats. Both hormonal schemes partially restored sniffing behavior in KA-lesioned subjects. Moreover, acute and chronic E2 administration in KA-treated rats resulted in increased vertical and horizontal activity of these animals in the open field test. Memory for object recognition was reduced following KA and was not restored by hormonal treatments. Acute, but not chronic, E2 coadministration with KA significantly impaired spatial performance in the water maze task, while KA alone had no effect. Both acute and chronic estradiol administration rescued hilar and CA1 neurons from KA-induced cell death. Chronic, but not acute, E2 increased neurofilament immunoreactivity in the mossy fibers of the dentate gyrus neurons, similarly to KA. Our results show that although estradiol administration in KA-treated rats has beneficial effects on cell survival, it has diverse effects on exploratory behavior, object, and spatial memory. Estradiol effects on KA-lesioned animals depended on the duration and timing of exposure to the hormone, implying different mechanisms of hormone actions.
Περιγραφή
Λέξεις-κλειδιά
Analysis of Variance, Animals, Brain Injuries/chemically induced/drug therapy/physiopathology, Estradiol/*metabolism/pharmacology, Exploratory Behavior/drug effects/*physiology, Female, Hippocampus/drug effects/pathology/*physiology, Kainic Acid, Maze Learning/drug effects/*physiology, Models, Animal, Neurons/drug effects/pathology/*physiology, Neuroprotective Agents/metabolism/pharmacology, Neurotoxicity Syndromes/drug therapy/*physiopathology, Neurotoxins, Ovariectomy, Rats, Rats, Wistar, Recognition (Psychology)/drug effects/*physiology, Space Perception/drug effects/physiology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/15907329
http://ac.els-cdn.com/S0018506X05000899/1-s2.0-S0018506X05000899-main.pdf?_tid=3cc4b2256188c26b3332fc4444fa7347&acdnat=1332926197_32ed2c7e376e488c1a11df248c217df6
http://ac.els-cdn.com/S0018506X05000899/1-s2.0-S0018506X05000899-main.pdf?_tid=3cc4b2256188c26b3332fc4444fa7347&acdnat=1332926197_32ed2c7e376e488c1a11df248c217df6
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής