Estrogens influence behavioral responses in a kainic acid model of neurotoxicity

Απλή σελίδα τεκμηρίου
dc.contributor.authorPapalexi, E.en
dc.contributor.authorAntoniou, K.en
dc.contributor.authorKitraki, E.en
dc.date.accessioned2015-11-24T19:18:04Z
dc.date.available2015-11-24T19:18:04Z
dc.identifier.issn0018-506X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21839
dc.rightsDefault Licence-
dc.subjectAnalysis of Varianceen
dc.subjectAnimalsen
dc.subjectBrain Injuries/chemically induced/drug therapy/physiopathologyen
dc.subjectEstradiol/*metabolism/pharmacologyen
dc.subjectExploratory Behavior/drug effects/*physiologyen
dc.subjectFemaleen
dc.subjectHippocampus/drug effects/pathology/*physiologyen
dc.subjectKainic Aciden
dc.subjectMaze Learning/drug effects/*physiologyen
dc.subjectModels, Animalen
dc.subjectNeurons/drug effects/pathology/*physiologyen
dc.subjectNeuroprotective Agents/metabolism/pharmacologyen
dc.subjectNeurotoxicity Syndromes/drug therapy/*physiopathologyen
dc.subjectNeurotoxinsen
dc.subjectOvariectomyen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectRecognition (Psychology)/drug effects/*physiologyen
dc.subjectSpace Perception/drug effects/physiologyen
dc.titleEstrogens influence behavioral responses in a kainic acid model of neurotoxicityen
heal.abstractThe behavioral and neuroprotective effects of 17beta-estradiol (E2), on ovariectomized rats treated with a subconvulsive dose (7 mg/kg bw, ip) of kainic acid (KA), were examined. Estradiol was administered either acutely (150 mug/rat, ip) along with KA, 14 days post-ovariectomy, or chronically (sc capsules providing proestrus estrogen levels in serum) starting at ovariectomy. Exploratory behavior, as deduced by sniffing in the open field test, was reduced in KA-treated rats. Both hormonal schemes partially restored sniffing behavior in KA-lesioned subjects. Moreover, acute and chronic E2 administration in KA-treated rats resulted in increased vertical and horizontal activity of these animals in the open field test. Memory for object recognition was reduced following KA and was not restored by hormonal treatments. Acute, but not chronic, E2 coadministration with KA significantly impaired spatial performance in the water maze task, while KA alone had no effect. Both acute and chronic estradiol administration rescued hilar and CA1 neurons from KA-induced cell death. Chronic, but not acute, E2 increased neurofilament immunoreactivity in the mossy fibers of the dentate gyrus neurons, similarly to KA. Our results show that although estradiol administration in KA-treated rats has beneficial effects on cell survival, it has diverse effects on exploratory behavior, object, and spatial memory. Estradiol effects on KA-lesioned animals depended on the duration and timing of exposure to the hormone, implying different mechanisms of hormone actions.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.yhbeh.2005.03.009-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15907329-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0018506X05000899/1-s2.0-S0018506X05000899-main.pdf?_tid=3cc4b2256188c26b3332fc4444fa7347&acdnat=1332926197_32ed2c7e376e488c1a11df248c217df6-
heal.journalNameHorm Behaven
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ