Estimation of LDL cholesterol based on the Friedewald formula and on apo B levels
Φόρτωση...
Ημερομηνία
Συγγραφείς
Bairaktari, E.
Hatzidimou, K.
Tzallas, C.
Vini, M.
Katsaraki, A.
Tselepis, A.
Elisaf, M.
Tsolas, O.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Clin Biochem
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Objectives: The plasma apolipoprotein B (apo B) concentrations have been considered to be a more accurate representation of atherogenic particles and it has been proposed that the formula LDL-C (mmol/L) = 0.41TC - 0.32TG + 1.70apo B - 0.27 is reliable for the estimation of LDL-C (Clin Chem 1997; 43: 308-15). We undertook the present study to investigate the reliability of this formula in a large number of hyperlipidemic patients. Design and methods: 1) The Friedewald formula (LDL-F) and the apo B-based formula (LDL-B) were compared with the P-quantification reference procedure in 130 individuals with a wide range of total cholesterol CTC) and triglyceride CTG) levels, and 2) the LDL-C levels obtained by the Friedewald formula were compared with those calculated by the apo B-based formula in 1010 individuals attending our outpatient lipid clinic. Results: The LDL-F and the LDL-B formulae for LDL-C estimation were found to be in good agreement with the beta -quantification (r = 0.96 and 0.97, respectively). The bias of each method plotted as a function of TG (up to 4.52 mmol/L) was found positive for the LDL-F, whereas the LDL-B was independent of the concentrations of TG. When a large number of individuals were examined, a good correlation between the two equations was found (n = 1010, r = 0.98). The difference between the two methods was not correlated with serum TG levels. However, it was correlated to serum TC, and apo B levels. Conclusions: The LDL-B formula is a more reliable and accurate method than the LDL-F formula, especially at To levels >2.26 mmol/L, although it underestimates LDL-C concentrations. Furthermore, this equation can be used in hypertriglyceridemic patients CTG >4.52 mmol/L) in whom the Friedewald equation is inaccurate. Copyright (C) 2000 The Canadian Society of Clinical Chemists.
Περιγραφή
Λέξεις-κλειδιά
ldl-cholesterol measurement, friedewald formula, apolipoprotein b, density-lipoprotein cholesterol, apolipoprotein-a-i, myocardial-infarction, heart-disease, framingham, plasma, risk, men
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000166009300005
http://ac.els-cdn.com/S0009912000001624/1-s2.0-S0009912000001624-main.pdf?_tid=1695aacd6cf4029f2b18baa3c9b2152b&acdnat=1333110950_ed60ca5f3cf455e8e178d5f797b40028
http://ac.els-cdn.com/S0009912000001624/1-s2.0-S0009912000001624-main.pdf?_tid=1695aacd6cf4029f2b18baa3c9b2152b&acdnat=1333110950_ed60ca5f3cf455e8e178d5f797b40028
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας