Estimation of LDL cholesterol based on the Friedewald formula and on apo B levels

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dc.contributor.authorBairaktari, E.en
dc.contributor.authorHatzidimou, K.en
dc.contributor.authorTzallas, C.en
dc.contributor.authorVini, M.en
dc.contributor.authorKatsaraki, A.en
dc.contributor.authorTselepis, A.en
dc.contributor.authorElisaf, M.en
dc.contributor.authorTsolas, O.en
dc.date.accessioned2015-11-24T16:58:00Z
dc.date.available2015-11-24T16:58:00Z
dc.identifier.issn0009-9120-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/10644
dc.rightsDefault Licence-
dc.subjectldl-cholesterol measurementen
dc.subjectfriedewald formulaen
dc.subjectapolipoprotein ben
dc.subjectdensity-lipoprotein cholesterolen
dc.subjectapolipoprotein-a-ien
dc.subjectmyocardial-infarctionen
dc.subjectheart-diseaseen
dc.subjectframinghamen
dc.subjectplasmaen
dc.subjectrisken
dc.subjectmenen
dc.titleEstimation of LDL cholesterol based on the Friedewald formula and on apo B levelsen
heal.abstractObjectives: The plasma apolipoprotein B (apo B) concentrations have been considered to be a more accurate representation of atherogenic particles and it has been proposed that the formula LDL-C (mmol/L) = 0.41TC - 0.32TG + 1.70apo B - 0.27 is reliable for the estimation of LDL-C (Clin Chem 1997; 43: 308-15). We undertook the present study to investigate the reliability of this formula in a large number of hyperlipidemic patients. Design and methods: 1) The Friedewald formula (LDL-F) and the apo B-based formula (LDL-B) were compared with the P-quantification reference procedure in 130 individuals with a wide range of total cholesterol CTC) and triglyceride CTG) levels, and 2) the LDL-C levels obtained by the Friedewald formula were compared with those calculated by the apo B-based formula in 1010 individuals attending our outpatient lipid clinic. Results: The LDL-F and the LDL-B formulae for LDL-C estimation were found to be in good agreement with the beta -quantification (r = 0.96 and 0.97, respectively). The bias of each method plotted as a function of TG (up to 4.52 mmol/L) was found positive for the LDL-F, whereas the LDL-B was independent of the concentrations of TG. When a large number of individuals were examined, a good correlation between the two equations was found (n = 1010, r = 0.98). The difference between the two methods was not correlated with serum TG levels. However, it was correlated to serum TC, and apo B levels. Conclusions: The LDL-B formula is a more reliable and accurate method than the LDL-F formula, especially at To levels >2.26 mmol/L, although it underestimates LDL-C concentrations. Furthermore, this equation can be used in hypertriglyceridemic patients CTG >4.52 mmol/L) in whom the Friedewald equation is inaccurate. Copyright (C) 2000 The Canadian Society of Clinical Chemists.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000166009300005-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0009912000001624/1-s2.0-S0009912000001624-main.pdf?_tid=1695aacd6cf4029f2b18baa3c9b2152b&acdnat=1333110950_ed60ca5f3cf455e8e178d5f797b40028-
heal.journalNameClin Biochemen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2000-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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