Effects of fish oil supplementation on kidney transplantation: a systematic review and meta-analysis of randomized, controlled trials
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Authors
Tatsioni, A.
Chung, M.
Sun, Y.
Kupelnick, B.
Lichtenstein, A. H.
Perrone, R.
Chew, P.
Lau, J.
Bonis, P. A.
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peer-reviewed
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J Am Soc Nephrol
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The objective of this study was to assess the effects of omega-3 fatty acid supplementation on various kidney transplant-related outcomes. A systematic review and meta-analysis was performed of published randomized, controlled trials (RCT). There were 16 kidney transplant RCT with a total of 812 patients. All trials evaluated fish oil with dosages that ranged from 1.2 to 5.4 g/d. No consistent benefits were observed for any outcome with the exception of a modest benefit on triglycerides. A meta-analysis of rejection episodes found no significant benefit on either early (<6 mo posttransplantation) or late episodes. The overall relative risk of having at least one rejection episode in those who received fish oil was 0.91 (95% confidence interval 0.74 to 1.10) in four studies with a follow-up of 1 yr. A meta-analysis of eight RCT of graft survival found no significant benefit (relative risk 1.00, 95% confidence interval 0.96 to 1.05). The available data (mostly derived from older studies with important methodologic limitations) do not demonstrate a consistent, clinically important benefit of fish oil in kidney transplantation.
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Keywords
Clinical Trials as Topic, *Dietary Supplements, Fatty Acids, Omega-3/metabolism, Fish Oils/*pharmacology, Follow-Up Studies, Glomerular Filtration Rate, Graft Rejection, Humans, Immunosuppressive Agents/administration & dosage, Kidney Diseases/mortality/therapy, Kidney Transplantation/*methods, Models, Statistical, Randomized Controlled Trials as Topic, Research Design, Risk, Treatment Outcome
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http://www.ncbi.nlm.nih.gov/pubmed/15958723
http://jasn.asnjournals.org/content/16/8/2462.full.pdf
http://jasn.asnjournals.org/content/16/8/2462.full.pdf
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής