Effects of fish oil supplementation on kidney transplantation: a systematic review and meta-analysis of randomized, controlled trials
| dc.contributor.author | Tatsioni, A. | en |
| dc.contributor.author | Chung, M. | en |
| dc.contributor.author | Sun, Y. | en |
| dc.contributor.author | Kupelnick, B. | en |
| dc.contributor.author | Lichtenstein, A. H. | en |
| dc.contributor.author | Perrone, R. | en |
| dc.contributor.author | Chew, P. | en |
| dc.contributor.author | Lau, J. | en |
| dc.contributor.author | Bonis, P. A. | en |
| dc.date.accessioned | 2015-11-24T19:21:15Z | |
| dc.date.available | 2015-11-24T19:21:15Z | |
| dc.identifier.issn | 1046-6673 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22091 | |
| dc.rights | Default Licence | - |
| dc.subject | Clinical Trials as Topic | en |
| dc.subject | *Dietary Supplements | en |
| dc.subject | Fatty Acids, Omega-3/metabolism | en |
| dc.subject | Fish Oils/*pharmacology | en |
| dc.subject | Follow-Up Studies | en |
| dc.subject | Glomerular Filtration Rate | en |
| dc.subject | Graft Rejection | en |
| dc.subject | Humans | en |
| dc.subject | Immunosuppressive Agents/administration & dosage | en |
| dc.subject | Kidney Diseases/mortality/therapy | en |
| dc.subject | Kidney Transplantation/*methods | en |
| dc.subject | Models, Statistical | en |
| dc.subject | Randomized Controlled Trials as Topic | en |
| dc.subject | Research Design | en |
| dc.subject | Risk | en |
| dc.subject | Treatment Outcome | en |
| dc.title | Effects of fish oil supplementation on kidney transplantation: a systematic review and meta-analysis of randomized, controlled trials | en |
| heal.abstract | The objective of this study was to assess the effects of omega-3 fatty acid supplementation on various kidney transplant-related outcomes. A systematic review and meta-analysis was performed of published randomized, controlled trials (RCT). There were 16 kidney transplant RCT with a total of 812 patients. All trials evaluated fish oil with dosages that ranged from 1.2 to 5.4 g/d. No consistent benefits were observed for any outcome with the exception of a modest benefit on triglycerides. A meta-analysis of rejection episodes found no significant benefit on either early (<6 mo posttransplantation) or late episodes. The overall relative risk of having at least one rejection episode in those who received fish oil was 0.91 (95% confidence interval 0.74 to 1.10) in four studies with a follow-up of 1 yr. A meta-analysis of eight RCT of graft survival found no significant benefit (relative risk 1.00, 95% confidence interval 0.96 to 1.05). The available data (mostly derived from older studies with important methodologic limitations) do not demonstrate a consistent, clinically important benefit of fish oil in kidney transplantation. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1681/ASN.2005020176 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15958723 | - |
| heal.identifier.secondary | http://jasn.asnjournals.org/content/16/8/2462.full.pdf | - |
| heal.journalName | J Am Soc Nephrol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2005 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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