Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin
Φόρτωση...
Ημερομηνία
Συγγραφείς
Minas, V.
Jeschke, U.
Kalantaridou, S. N.
Richter, D. U.
Reimer, T.
Mylonas, I.
Friese, K.
Makrigiannakis, A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Mol Hum Reprod
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Human reproduction is remarkably inefficient, with more than half of spontaneous conceptions failing to complete the first trimester. However, little is known on the molecular events that take place at the implantation site during abortion. Here, we examined the hypothesis that the expression of the proapoptotic Fas/FasL system at the implantation site is impaired in abortions. We found that, in contrast to normal pregnancy, abortive deciduas contain leukocytes that are positive for FasL and extravillous trophoblasts (EVTs), which show increased expression of Fas and increased rates of apoptosis. In addition, the neuropeptides, corticotropin-releasing hormone and urocortin, were elevated in placental material obtained from abortions. In vitro, these peptides induced the expression of FasL in decidual lymphocytes (DL) obtained from elective termination of pregnancy placentas and thus potentiated the cells' ability to induce Fas-mediated apoptosis in an EVT-based hybridoma cell line. Finally, DL from abortion sites effectively induced apoptosis of EVT without prior treatment. It is possible that these events may impede successful early placentation and thus contribute to the pathophysiology of human abortion.
Περιγραφή
Λέξεις-κλειδιά
Abortion, Induced, Abortion, Spontaneous/genetics/metabolism/*physiopathology, Adult, Apoptosis/genetics/*physiology, Blotting, Western, Cells, Cultured, Corticotropin-Releasing Hormone/genetics/metabolism/physiology, Fas Ligand Protein/genetics/*metabolism, Female, Flow Cytometry, Gene Expression, Humans, Immunohistochemistry, In Situ Nick-End Labeling, Leukocytes/cytology/*metabolism, Pregnancy, Reverse Transcriptase Polymerase Chain Reaction, Trophoblasts/cytology/*metabolism, Urocortins/genetics/metabolism/physiology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17704118
http://molehr.oxfordjournals.org/content/13/9/663.full.pdf
http://molehr.oxfordjournals.org/content/13/9/663.full.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής