Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin

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dc.contributor.authorMinas, V.en
dc.contributor.authorJeschke, U.en
dc.contributor.authorKalantaridou, S. N.en
dc.contributor.authorRichter, D. U.en
dc.contributor.authorReimer, T.en
dc.contributor.authorMylonas, I.en
dc.contributor.authorFriese, K.en
dc.contributor.authorMakrigiannakis, A.en
dc.date.accessioned2015-11-24T19:38:40Z
dc.date.available2015-11-24T19:38:40Z
dc.identifier.issn1360-9947-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24168
dc.rightsDefault Licence-
dc.subjectAbortion, Induceden
dc.subjectAbortion, Spontaneous/genetics/metabolism/*physiopathologyen
dc.subjectAdulten
dc.subjectApoptosis/genetics/*physiologyen
dc.subjectBlotting, Westernen
dc.subjectCells, Cultureden
dc.subjectCorticotropin-Releasing Hormone/genetics/metabolism/physiologyen
dc.subjectFas Ligand Protein/genetics/*metabolismen
dc.subjectFemaleen
dc.subjectFlow Cytometryen
dc.subjectGene Expressionen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectIn Situ Nick-End Labelingen
dc.subjectLeukocytes/cytology/*metabolismen
dc.subjectPregnancyen
dc.subjectReverse Transcriptase Polymerase Chain Reactionen
dc.subjectTrophoblasts/cytology/*metabolismen
dc.subjectUrocortins/genetics/metabolism/physiologyen
dc.titleAbortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortinen
heal.abstractHuman reproduction is remarkably inefficient, with more than half of spontaneous conceptions failing to complete the first trimester. However, little is known on the molecular events that take place at the implantation site during abortion. Here, we examined the hypothesis that the expression of the proapoptotic Fas/FasL system at the implantation site is impaired in abortions. We found that, in contrast to normal pregnancy, abortive deciduas contain leukocytes that are positive for FasL and extravillous trophoblasts (EVTs), which show increased expression of Fas and increased rates of apoptosis. In addition, the neuropeptides, corticotropin-releasing hormone and urocortin, were elevated in placental material obtained from abortions. In vitro, these peptides induced the expression of FasL in decidual lymphocytes (DL) obtained from elective termination of pregnancy placentas and thus potentiated the cells' ability to induce Fas-mediated apoptosis in an EVT-based hybridoma cell line. Finally, DL from abortion sites effectively induced apoptosis of EVT without prior treatment. It is possible that these events may impede successful early placentation and thus contribute to the pathophysiology of human abortion.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1093/molehr/gam054-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17704118-
heal.identifier.secondaryhttp://molehr.oxfordjournals.org/content/13/9/663.full.pdf-
heal.journalNameMol Hum Reproden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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