Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis
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Fang, Y.
Rivadeneira, F.
van Meurs, J. B.
Pols, H. A.
Ioannidis, J. P.
Uitterlinden, A. G.
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peer-reviewed
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Bone
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INTRODUCTION: Fracture is the major clinical outcome of osteoporosis. The vitamin D receptor (VDR) gene is thought to be a candidate gene for osteoporosis. Many genetic studies have suggested an association of VDR polymorphisms and osteoporosis, but evidence remains conflicting. MATERIALS AND METHODS: We searched published studies from 1996 to September 2005 through PubMed and evaluated the genetic effect of the BsmI and TaqI polymorphism of VDR on fracture risk in a meta-analysis. Thirteen studies with a total of 20 eligible comparisons (1632 fracture cases and 5203 controls) were analyzed with fixed and random effects models. RESULT: No evidence of relationship between the VDR BsmI or TaqI polymorphism and fracture risk was observed with any genetic model. The odds ratio (95% confidence interval) of b-allele versus B-allele was 0.98 (0.86-1.12) with random effects calculations. There was significant between-study heterogeneity. Small studies did not differ significantly from larger ones. CONCLUSION: No relationship of the VDR BsmI or TaqI polymorphism and fracture risk was found in the meta-analysis of published data.
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Keywords
Adult, Aged, Aged, 80 and over, Deoxyribonucleases, Type II Site-Specific/metabolism, Female, Fractures, Bone/*genetics, Gene Frequency, Genetic Predisposition to Disease/genetics, Humans, Male, Middle Aged, Odds Ratio, Osteoporosis/genetics, *Polymorphism, Restriction Fragment Length, Receptors, Calcitriol/*genetics
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http://www.ncbi.nlm.nih.gov/pubmed/16769262
http://ac.els-cdn.com/S8756328206004145/1-s2.0-S8756328206004145-main.pdf?_tid=6583be43c469e20f85a1fcdc7b8938e6&acdnat=1333364235_16dbb28a1f53d14dc53af56b81add44b
http://ac.els-cdn.com/S8756328206004145/1-s2.0-S8756328206004145-main.pdf?_tid=6583be43c469e20f85a1fcdc7b8938e6&acdnat=1333364235_16dbb28a1f53d14dc53af56b81add44b
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής