Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis

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dc.contributor.authorFang, Y.en
dc.contributor.authorRivadeneira, F.en
dc.contributor.authorvan Meurs, J. B.en
dc.contributor.authorPols, H. A.en
dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorUitterlinden, A. G.en
dc.date.accessioned2015-11-24T19:41:27Z
dc.date.available2015-11-24T19:41:27Z
dc.identifier.issn8756-3282-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24483
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectDeoxyribonucleases, Type II Site-Specific/metabolismen
dc.subjectFemaleen
dc.subjectFractures, Bone/*geneticsen
dc.subjectGene Frequencyen
dc.subjectGenetic Predisposition to Disease/geneticsen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOdds Ratioen
dc.subjectOsteoporosis/geneticsen
dc.subject*Polymorphism, Restriction Fragment Lengthen
dc.subjectReceptors, Calcitriol/*geneticsen
dc.titleVitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysisen
heal.abstractINTRODUCTION: Fracture is the major clinical outcome of osteoporosis. The vitamin D receptor (VDR) gene is thought to be a candidate gene for osteoporosis. Many genetic studies have suggested an association of VDR polymorphisms and osteoporosis, but evidence remains conflicting. MATERIALS AND METHODS: We searched published studies from 1996 to September 2005 through PubMed and evaluated the genetic effect of the BsmI and TaqI polymorphism of VDR on fracture risk in a meta-analysis. Thirteen studies with a total of 20 eligible comparisons (1632 fracture cases and 5203 controls) were analyzed with fixed and random effects models. RESULT: No evidence of relationship between the VDR BsmI or TaqI polymorphism and fracture risk was observed with any genetic model. The odds ratio (95% confidence interval) of b-allele versus B-allele was 0.98 (0.86-1.12) with random effects calculations. There was significant between-study heterogeneity. Small studies did not differ significantly from larger ones. CONCLUSION: No relationship of the VDR BsmI or TaqI polymorphism and fracture risk was found in the meta-analysis of published data.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.bone.2006.04.016-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16769262-
heal.identifier.secondaryhttp://ac.els-cdn.com/S8756328206004145/1-s2.0-S8756328206004145-main.pdf?_tid=6583be43c469e20f85a1fcdc7b8938e6&acdnat=1333364235_16dbb28a1f53d14dc53af56b81add44b-
heal.journalNameBoneen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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