Matrix metalloproteinases in carcinoma of unknown primary
Φόρτωση...
Ημερομηνία
Συγγραφείς
Karavasilis, V.
Malamou-Mitsi, V.
Briasoulis, E.
Tsanou, E.
Kitsou, E.
Kalofonos, H.
Fountzilas, G.
Fotsis, T.
Pavlidis, N.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Cancer
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: The purpose was to study proteolysis-related molecules, matrix metalloproteinase-2 (MMP-2) and MMP-9 and tissue inhibitor of metalloproteinases-1 (TIMP-1), in carcinoma of unknown primary (CUP). METHODS: Paraffin-embedded tumor material from 75 patients diagnosed with CUP was used. Tumor histologies were adenocarcinoma (77%), undifferentiated carcinoma (19%), and squamous cell carcinoma (4%) and patients were categorized into favorable (62%) and unfavorable (38%) subsets. The tissue expression of MMP-2, MMP-9, and TIMP-1 was assessed by use of specific monoclonal antibodies and evaluated by means of a visual staining score. The expression of molecules studied was analyzed against clinicopathological data. RESULTS: MMP-2 was found expressed in 69% (strong expression in 49%), MMP-9 in 49% (strong in 36%), and TIMP-1 in 79% (strong in 44%) of studied cases. The expression of MMP-2 correlated positively with MMP-9. TIMP-1 was significantly higher in unfavorable compared with favorable tumors and was associated with a shorter survival of patients (7.5 vs. 12 mos). No other associations were detected. CONCLUSIONS: MMP-2, MMP-9, and TIMP-1 are widely expressed in CUP, suggesting an essential role of proteolysis in these tumors. TIMP-1 may be considered a possible marker of poor prognosis in CUP patients.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Aged, 80 and over, Carcinoma/*enzymology/*secondary, Female, Humans, Immunohistochemistry, Male, Matrix Metalloproteinases/*metabolism, Middle Aged, Neoplasms, Unknown Primary/*enzymology, Prognosis, Tissue Inhibitor of Metalloproteinases/metabolism, Tumor Markers, Biological/analysis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16220559
http://onlinelibrary.wiley.com/store/10.1002/cncr.21454/asset/21454_ftp.pdf?v=1&t=h0p0dpyu&s=8cf753d10afbaa0eec1fb8ed90d174d4cbd7fb6a
http://onlinelibrary.wiley.com/store/10.1002/cncr.21454/asset/21454_ftp.pdf?v=1&t=h0p0dpyu&s=8cf753d10afbaa0eec1fb8ed90d174d4cbd7fb6a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής