Matrix metalloproteinases in carcinoma of unknown primary
| dc.contributor.author | Karavasilis, V. | en |
| dc.contributor.author | Malamou-Mitsi, V. | en |
| dc.contributor.author | Briasoulis, E. | en |
| dc.contributor.author | Tsanou, E. | en |
| dc.contributor.author | Kitsou, E. | en |
| dc.contributor.author | Kalofonos, H. | en |
| dc.contributor.author | Fountzilas, G. | en |
| dc.contributor.author | Fotsis, T. | en |
| dc.contributor.author | Pavlidis, N. | en |
| dc.date.accessioned | 2015-11-24T19:05:14Z | |
| dc.date.available | 2015-11-24T19:05:14Z | |
| dc.identifier.issn | 0008-543X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20163 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Aged, 80 and over | en |
| dc.subject | Carcinoma/*enzymology/*secondary | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Male | en |
| dc.subject | Matrix Metalloproteinases/*metabolism | en |
| dc.subject | Middle Aged | en |
| dc.subject | Neoplasms, Unknown Primary/*enzymology | en |
| dc.subject | Prognosis | en |
| dc.subject | Tissue Inhibitor of Metalloproteinases/metabolism | en |
| dc.subject | Tumor Markers, Biological/analysis | en |
| dc.title | Matrix metalloproteinases in carcinoma of unknown primary | en |
| heal.abstract | BACKGROUND: The purpose was to study proteolysis-related molecules, matrix metalloproteinase-2 (MMP-2) and MMP-9 and tissue inhibitor of metalloproteinases-1 (TIMP-1), in carcinoma of unknown primary (CUP). METHODS: Paraffin-embedded tumor material from 75 patients diagnosed with CUP was used. Tumor histologies were adenocarcinoma (77%), undifferentiated carcinoma (19%), and squamous cell carcinoma (4%) and patients were categorized into favorable (62%) and unfavorable (38%) subsets. The tissue expression of MMP-2, MMP-9, and TIMP-1 was assessed by use of specific monoclonal antibodies and evaluated by means of a visual staining score. The expression of molecules studied was analyzed against clinicopathological data. RESULTS: MMP-2 was found expressed in 69% (strong expression in 49%), MMP-9 in 49% (strong in 36%), and TIMP-1 in 79% (strong in 44%) of studied cases. The expression of MMP-2 correlated positively with MMP-9. TIMP-1 was significantly higher in unfavorable compared with favorable tumors and was associated with a shorter survival of patients (7.5 vs. 12 mos). No other associations were detected. CONCLUSIONS: MMP-2, MMP-9, and TIMP-1 are widely expressed in CUP, suggesting an essential role of proteolysis in these tumors. TIMP-1 may be considered a possible marker of poor prognosis in CUP patients. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1002/cncr.21454 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/16220559 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/cncr.21454/asset/21454_ftp.pdf?v=1&t=h0p0dpyu&s=8cf753d10afbaa0eec1fb8ed90d174d4cbd7fb6a | - |
| heal.journalName | Cancer | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2005 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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