Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats
Φόρτωση...
Ημερομηνία
Συγγραφείς
Agelaki, M. G.
Pantos, C.
Korantzopoulos, P.
Tsalikakis, D. G.
Baltogiannis, G. G.
Fotopoulos, A.
Kolettis, T. M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
European Journal of Pharmacology
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The effects of dronedarone, a non-iodinated derivative of amiodarone, on ventricular tachycardia and ventricular fibrillation post-myocardial infarction are not well established. Fifty-five Wistar rats were randomly allocated to a 2-week oral treatment with either vehicle (n=18), amiodarone (30 mg/kg, n=20), or dronedarone (30 mg/kg, n=17). After acute coronary artery ligation, a single-lead electrocardiogram was continuously recorded for 24 h and episodes of ventricular tachycardia/fibrillation as well as mortality rates were analysed. Monophasic action potential recordings were obtained from the left ventricular epicardium at baseline and 24 h post-myocardial infarction. Thyroid hormones and catecholamines were measured using radioimmunoassay. Thyroid function was similar in the 3 groups. Compared to controls, amiodarone and dronedarone equally decreased the number of ventricular tachycardia/fibrillation episodes by approximately 75%. Both agents prevented the increase in monophasic action potential duration and in beat-to-beat variation. Norepinephrine levels were lower only after amiodarone treatment. Despite the observed antiarrhythmic effect, total mortality did not differ between groups (38.8% in controls, 30.0% in the amiodarone group and 58.8% in the dronedarone group), because of excess bradyarrhythmic mortality in both drug groups that reached significance in the dronedarone group. Dronedarone and amiodarone display similar antiarrhythmic efficacy post-myocardial infarction, partly by preventing repolarization inhomogeneity. However, dronedarone increases bradyarrhythmic mortality possibly secondary to its negative inotropic effects.
Περιγραφή
Λέξεις-κλειδιά
Action Potentials/drug effects, Amiodarone/*analogs & derivatives/pharmacology/*therapeutic use, Animals, Anti-Arrhythmia Agents/pharmacology/*therapeutic use, Disease Models, Animal, Electrocardiography, Ambulatory, Epinephrine/metabolism, Female, Myocardial Infarction/complications/*drug therapy/mortality, Norepinephrine/metabolism, Radioimmunoassay, Random Allocation, Rats, Rats, Wistar, Tachycardia, Ventricular/drug therapy, Telemetry, Thyroid Hormones/metabolism, Ventricular Fibrillation/drug therapy
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17391666
http://ac.els-cdn.com/S0014299907003032/1-s2.0-S0014299907003032-main.pdf?_tid=784d7682229f692a559052cc0f1f8617&acdnat=1333962969_11fe7963b3289e06ff27eb40b417dd60
http://ac.els-cdn.com/S0014299907003032/1-s2.0-S0014299907003032-main.pdf?_tid=784d7682229f692a559052cc0f1f8617&acdnat=1333962969_11fe7963b3289e06ff27eb40b417dd60
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής