Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats

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dc.contributor.authorAgelaki, M. G.en
dc.contributor.authorPantos, C.en
dc.contributor.authorKorantzopoulos, P.en
dc.contributor.authorTsalikakis, D. G.en
dc.contributor.authorBaltogiannis, G. G.en
dc.contributor.authorFotopoulos, A.en
dc.contributor.authorKolettis, T. M.en
dc.date.accessioned2015-11-24T19:28:59Z
dc.date.available2015-11-24T19:28:59Z
dc.identifier.issn0014-2999-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22939
dc.rightsDefault Licence-
dc.subjectAction Potentials/drug effectsen
dc.subjectAmiodarone/*analogs & derivatives/pharmacology/*therapeutic useen
dc.subjectAnimalsen
dc.subjectAnti-Arrhythmia Agents/pharmacology/*therapeutic useen
dc.subjectDisease Models, Animalen
dc.subjectElectrocardiography, Ambulatoryen
dc.subjectEpinephrine/metabolismen
dc.subjectFemaleen
dc.subjectMyocardial Infarction/complications/*drug therapy/mortalityen
dc.subjectNorepinephrine/metabolismen
dc.subjectRadioimmunoassayen
dc.subjectRandom Allocationen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectTachycardia, Ventricular/drug therapyen
dc.subjectTelemetryen
dc.subjectThyroid Hormones/metabolismen
dc.subjectVentricular Fibrillation/drug therapyen
dc.titleComparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in ratsen
heal.abstractThe effects of dronedarone, a non-iodinated derivative of amiodarone, on ventricular tachycardia and ventricular fibrillation post-myocardial infarction are not well established. Fifty-five Wistar rats were randomly allocated to a 2-week oral treatment with either vehicle (n=18), amiodarone (30 mg/kg, n=20), or dronedarone (30 mg/kg, n=17). After acute coronary artery ligation, a single-lead electrocardiogram was continuously recorded for 24 h and episodes of ventricular tachycardia/fibrillation as well as mortality rates were analysed. Monophasic action potential recordings were obtained from the left ventricular epicardium at baseline and 24 h post-myocardial infarction. Thyroid hormones and catecholamines were measured using radioimmunoassay. Thyroid function was similar in the 3 groups. Compared to controls, amiodarone and dronedarone equally decreased the number of ventricular tachycardia/fibrillation episodes by approximately 75%. Both agents prevented the increase in monophasic action potential duration and in beat-to-beat variation. Norepinephrine levels were lower only after amiodarone treatment. Despite the observed antiarrhythmic effect, total mortality did not differ between groups (38.8% in controls, 30.0% in the amiodarone group and 58.8% in the dronedarone group), because of excess bradyarrhythmic mortality in both drug groups that reached significance in the dronedarone group. Dronedarone and amiodarone display similar antiarrhythmic efficacy post-myocardial infarction, partly by preventing repolarization inhomogeneity. However, dronedarone increases bradyarrhythmic mortality possibly secondary to its negative inotropic effects.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.ejphar.2007.02.052-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17391666-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0014299907003032/1-s2.0-S0014299907003032-main.pdf?_tid=784d7682229f692a559052cc0f1f8617&acdnat=1333962969_11fe7963b3289e06ff27eb40b417dd60-
heal.journalNameEuropean Journal of Pharmacologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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