The role of cadherin/catenin complex in malignant melanoma
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Date
Authors
Bonitsis, N.
Batistatou, A.
Karantima, S.
Charalabopoulos, K.
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peer-reviewed
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Exp Oncol
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In the present review article the role of cadherin/catenin complex in cases of malignant melanoma is discussed in some detail. Cadherins represent the most important superfamily of adhesion molecules with epithelial E-cadherin being the most studied. Its role in normal state as well as in cancer invasion and metastasis and some other pathologies is crucial. E-cadherin expression is altered in malignant melanomas and its downregulation or absence is associated with melanoma invasion and metastasis potential. A shift from E-cadherin expression to neural N-cadherin expression in melanocytes is also detected in malignant melanomas formation. In addition, a discussion regarding the role of placental P-cadherin and vascular endothelial VE-cadherin as well as the recently identified molecule of dysadherin, is attempted in brief.
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Keywords
Cadherins/analysis/*metabolism, Catenins/analysis/*metabolism, Humans, Melanoma/metabolism/*pathology, Skin Neoplasms/metabolism/*pathology
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Citation
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http://www.ncbi.nlm.nih.gov/pubmed/17080010
Language
en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής