The role of cadherin/catenin complex in malignant melanoma
| dc.contributor.author | Bonitsis, N. | en |
| dc.contributor.author | Batistatou, A. | en |
| dc.contributor.author | Karantima, S. | en |
| dc.contributor.author | Charalabopoulos, K. | en |
| dc.date.accessioned | 2015-11-24T19:31:42Z | |
| dc.date.available | 2015-11-24T19:31:42Z | |
| dc.identifier.issn | 1812-9269 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23309 | |
| dc.rights | Default Licence | - |
| dc.subject | Cadherins/analysis/*metabolism | en |
| dc.subject | Catenins/analysis/*metabolism | en |
| dc.subject | Humans | en |
| dc.subject | Melanoma/metabolism/*pathology | en |
| dc.subject | Skin Neoplasms/metabolism/*pathology | en |
| dc.title | The role of cadherin/catenin complex in malignant melanoma | en |
| heal.abstract | In the present review article the role of cadherin/catenin complex in cases of malignant melanoma is discussed in some detail. Cadherins represent the most important superfamily of adhesion molecules with epithelial E-cadherin being the most studied. Its role in normal state as well as in cancer invasion and metastasis and some other pathologies is crucial. E-cadherin expression is altered in malignant melanomas and its downregulation or absence is associated with melanoma invasion and metastasis potential. A shift from E-cadherin expression to neural N-cadherin expression in melanocytes is also detected in malignant melanomas formation. In addition, a discussion regarding the role of placental P-cadherin and vascular endothelial VE-cadherin as well as the recently identified molecule of dysadherin, is attempted in brief. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17080010 | - |
| heal.journalName | Exp Oncol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2006 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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