Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study
Φόρτωση...
Ημερομηνία
Συγγραφείς
Elbaz, A.
Nelson, L. M.
Payami, H.
Ioannidis, J. P.
Fiske, B. K.
Annesi, G.
Carmine Belin, A.
Factor, S. A.
Ferrarese, C.
Hadjigeorgiou, G. M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Lancet Neurol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain. METHODS: Investigators from three Michael J Fox Foundation for Parkinson's Research-funded genetics consortia-comprising 14 teams-contributed DNA samples from 5526 patients with Parkinson's disease and 6682 controls, which were genotyped for the 13 SNPs. Most (88%) participants were of white, non-Hispanic descent. We assessed log-additive genetic effects using fixed and random effects models stratified by team and ethnic origin, and tested for heterogeneity across strata. A meta-analysis was undertaken that incorporated data from the original genome-wide study as well as subsequent replication studies. FINDINGS: In fixed and random-effects models no associations with any of the 13 SNPs were identified (odds ratios 0.89 to 1.09). Heterogeneity between studies and between ethnic groups was low for all SNPs. Subgroup analyses by age at study entry, ethnic origin, sex, and family history did not show any consistent associations. In our meta-analysis, no SNP showed significant association (summary odds ratios 0.95 to 1.08); there was little heterogeneity except for SNP rs7520966. INTERPRETATION: Our results do not lend support to the finding that the 13 SNPs reported in the original genome-wide association study are genetic susceptibility factors for Parkinson's disease.
Περιγραφή
Λέξεις-κλειδιά
Aged, Confidence Intervals, Female, *Genetic Predisposition to Disease, Humans, *International Cooperation, Linkage Disequilibrium, Male, Meta-Analysis as Topic, Middle Aged, Odds Ratio, Parkinson Disease/epidemiology/*genetics, Polymorphism, Single Nucleotide/*genetics
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17052658
http://ac.els-cdn.com/S1474442206705798/1-s2.0-S1474442206705798-main.pdf?_tid=12843a73da71046273d4d4c87f7f0ec5&acdnat=1333364186_04a43746d09789922e5a85bee3c849e1
http://ac.els-cdn.com/S1474442206705798/1-s2.0-S1474442206705798-main.pdf?_tid=12843a73da71046273d4d4c87f7f0ec5&acdnat=1333364186_04a43746d09789922e5a85bee3c849e1
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής