Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study

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dc.contributor.authorElbaz, A.en
dc.contributor.authorNelson, L. M.en
dc.contributor.authorPayami, H.en
dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorFiske, B. K.en
dc.contributor.authorAnnesi, G.en
dc.contributor.authorCarmine Belin, A.en
dc.contributor.authorFactor, S. A.en
dc.contributor.authorFerrarese, C.en
dc.contributor.authorHadjigeorgiou, G. M.en
dc.contributor.authorHiggins, D. S.en
dc.contributor.authorKawakami, H.en
dc.contributor.authorKruger, R.en
dc.contributor.authorMarder, K. S.en
dc.contributor.authorMayeux, R. P.en
dc.contributor.authorMellick, G. D.en
dc.contributor.authorNutt, J. G.en
dc.contributor.authorRitz, B.en
dc.contributor.authorSamii, A.en
dc.contributor.authorTanner, C. M.en
dc.contributor.authorVan Broeckhoven, C.en
dc.contributor.authorVan Den Eeden, S. K.en
dc.contributor.authorWirdefeldt, K.en
dc.contributor.authorZabetian, C. P.en
dc.contributor.authorDehem, M.en
dc.contributor.authorMontimurro, J. S.en
dc.contributor.authorSouthwick, A.en
dc.contributor.authorMyers, R. M.en
dc.contributor.authorTrikalinos, T. A.en
dc.date.accessioned2015-11-24T19:08:19Z
dc.date.available2015-11-24T19:08:19Z
dc.identifier.issn1474-4422-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20517
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectConfidence Intervalsen
dc.subjectFemaleen
dc.subject*Genetic Predisposition to Diseaseen
dc.subjectHumansen
dc.subject*International Cooperationen
dc.subjectLinkage Disequilibriumen
dc.subjectMaleen
dc.subjectMeta-Analysis as Topicen
dc.subjectMiddle Ageden
dc.subjectOdds Ratioen
dc.subjectParkinson Disease/epidemiology/*geneticsen
dc.subjectPolymorphism, Single Nucleotide/*geneticsen
dc.titleLack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international studyen
heal.abstractBACKGROUND: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain. METHODS: Investigators from three Michael J Fox Foundation for Parkinson's Research-funded genetics consortia-comprising 14 teams-contributed DNA samples from 5526 patients with Parkinson's disease and 6682 controls, which were genotyped for the 13 SNPs. Most (88%) participants were of white, non-Hispanic descent. We assessed log-additive genetic effects using fixed and random effects models stratified by team and ethnic origin, and tested for heterogeneity across strata. A meta-analysis was undertaken that incorporated data from the original genome-wide study as well as subsequent replication studies. FINDINGS: In fixed and random-effects models no associations with any of the 13 SNPs were identified (odds ratios 0.89 to 1.09). Heterogeneity between studies and between ethnic groups was low for all SNPs. Subgroup analyses by age at study entry, ethnic origin, sex, and family history did not show any consistent associations. In our meta-analysis, no SNP showed significant association (summary odds ratios 0.95 to 1.08); there was little heterogeneity except for SNP rs7520966. INTERPRETATION: Our results do not lend support to the finding that the 13 SNPs reported in the original genome-wide association study are genetic susceptibility factors for Parkinson's disease.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/S1474-4422(06)70579-8-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17052658-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1474442206705798/1-s2.0-S1474442206705798-main.pdf?_tid=12843a73da71046273d4d4c87f7f0ec5&acdnat=1333364186_04a43746d09789922e5a85bee3c849e1-
heal.journalNameLancet Neurolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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