CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype
Φόρτωση...
Ημερομηνία
Συγγραφείς
Xita, N.
Lazaros, L.
Georgiou, I.
Tsatsoulis, A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Fertil Steril
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: To evaluate the possible contribution of the (TTTA)n polymorphism of aromatase gene (CYP19) to the hyperandrogenic phenotype of polycystic ovary syndrome (PCOS). DESIGN: Case-control study. SETTING: Endocrine outpatients' clinic of a tertiary university hospital. PATIENT(S): One hundred eighty women with PCOS and 160 healthy controls of reproductive age. INTERVENTION(S): Blood sampling for genotype analysis, and measurement of androgens, E(2), LH, FSH, and fasting glucose and insulin. MAIN OUTCOME MEASURE(S): Frequency of the CYP19(TTTA)n polymorphism and association with hormone concentrations. RESULT(S): Women with PCOS tended to have more frequently short (TTTA)n alleles (with nine or fewer repeats) than healthy controls (33.1% vs. 29.5%), although the difference was not statistically significant. However, patients in the highest quartile for serum T were more frequently homozygous for short alleles compared with controls (59.1% vs. 42.1%) and patients in lower quartiles (59.1% vs. 36.9%). Furthermore, the patients homozygous for short alleles had higher T/E(2) ratios, higher T levels, and higher LH/FSH ratios compared with those with longer alleles. CONCLUSION(S): Although CYP19 may not be a major genetic determinant of PCOS, it may act as a genetic modifier of the hyperandrogenic phenotype of PCOS. The presence of short CYP19(TTTA)n alleles may contribute to prenatal androgenization programming the development of PCOS phenotype in adult life.
Περιγραφή
Λέξεις-κλειδιά
Adolescent, Adult, Alleles, Aromatase/*genetics, Case-Control Studies, Female, Gene Frequency, Genetic Markers/genetics, Humans, *Phenotype, Polycystic Ovary Syndrome/diagnosis/*enzymology/*genetics, Polymorphism, Genetic/genetics, Young Adult
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/19324338
http://ac.els-cdn.com/S0015028209002738/1-s2.0-S0015028209002738-main.pdf?_tid=b85cd36ad8f303e35998da2b1ec7636d&acdnat=1333347559_ad37e03912ad968614bdeb7a6582f526
http://ac.els-cdn.com/S0015028209002738/1-s2.0-S0015028209002738-main.pdf?_tid=b85cd36ad8f303e35998da2b1ec7636d&acdnat=1333347559_ad37e03912ad968614bdeb7a6582f526
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής