CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype
| dc.contributor.author | Xita, N. | en |
| dc.contributor.author | Lazaros, L. | en |
| dc.contributor.author | Georgiou, I. | en |
| dc.contributor.author | Tsatsoulis, A. | en |
| dc.date.accessioned | 2015-11-24T19:25:41Z | |
| dc.date.available | 2015-11-24T19:25:41Z | |
| dc.identifier.issn | 1556-5653 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22647 | |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Adult | en |
| dc.subject | Alleles | en |
| dc.subject | Aromatase/*genetics | en |
| dc.subject | Case-Control Studies | en |
| dc.subject | Female | en |
| dc.subject | Gene Frequency | en |
| dc.subject | Genetic Markers/genetics | en |
| dc.subject | Humans | en |
| dc.subject | *Phenotype | en |
| dc.subject | Polycystic Ovary Syndrome/diagnosis/*enzymology/*genetics | en |
| dc.subject | Polymorphism, Genetic/genetics | en |
| dc.subject | Young Adult | en |
| dc.title | CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype | en |
| heal.abstract | OBJECTIVE: To evaluate the possible contribution of the (TTTA)n polymorphism of aromatase gene (CYP19) to the hyperandrogenic phenotype of polycystic ovary syndrome (PCOS). DESIGN: Case-control study. SETTING: Endocrine outpatients' clinic of a tertiary university hospital. PATIENT(S): One hundred eighty women with PCOS and 160 healthy controls of reproductive age. INTERVENTION(S): Blood sampling for genotype analysis, and measurement of androgens, E(2), LH, FSH, and fasting glucose and insulin. MAIN OUTCOME MEASURE(S): Frequency of the CYP19(TTTA)n polymorphism and association with hormone concentrations. RESULT(S): Women with PCOS tended to have more frequently short (TTTA)n alleles (with nine or fewer repeats) than healthy controls (33.1% vs. 29.5%), although the difference was not statistically significant. However, patients in the highest quartile for serum T were more frequently homozygous for short alleles compared with controls (59.1% vs. 42.1%) and patients in lower quartiles (59.1% vs. 36.9%). Furthermore, the patients homozygous for short alleles had higher T/E(2) ratios, higher T levels, and higher LH/FSH ratios compared with those with longer alleles. CONCLUSION(S): Although CYP19 may not be a major genetic determinant of PCOS, it may act as a genetic modifier of the hyperandrogenic phenotype of PCOS. The presence of short CYP19(TTTA)n alleles may contribute to prenatal androgenization programming the development of PCOS phenotype in adult life. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.fertnstert.2009.01.147 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19324338 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0015028209002738/1-s2.0-S0015028209002738-main.pdf?_tid=b85cd36ad8f303e35998da2b1ec7636d&acdnat=1333347559_ad37e03912ad968614bdeb7a6582f526 | - |
| heal.journalName | Fertil Steril | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2010 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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