P21(waf1/cip1) protein expression in normal, hyperplastic and malignant endometrium. Correlation with hormone receptor status, c-erbB-2 oncoprotein, bcl-2 and other cell cycle related proteins (Rb, p53, Ki-67, PCNA)
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Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Exp Oncol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Defects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumor progression. p21(waf1/cip1) is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21 (waf1/cip1) expression has been investigated, immunohistochemically in a series of 115 endometrial carcinomas, 62 cases of endometrial hyperplasias, and 62 cases of normal endometium. (33 in proliferative phase and 29 in secretoty). The association between p21(waf1/cip1) expression with hormone receptor status, c-erbB-2 and other cell cycle, related proteins p53, Rb, Ki-67, PCNA) was assessed by univariate analysis. Nuclear p21 (waf1/cip1) expression was statistically higher in the group of carcinomas compared with normal proliferative (p=0.005) and secretory (p=0.0012) endometrium. In addition, this expression was higher in hyperplastic lesions compared with normal proliferative (p=0.02) and secretory (p=0.04) endometrium. A statistically significant positive relationship of p21(waf1/cip1) expression with progesterone receptor status (p=0.007), p53 protein (p=0.001), pRb (p<0.0001) and the two proliferative associated indices Ki-67 and PCNA (p<0.0001) was observed. These data indicate that the expression of p21 (waf1/cip1) protein seems to be an early event in endometrial carcinogenesis and is strongly associated with other cell cycle related proteins.
Περιγραφή
Λέξεις-κλειδιά
p21 (waf1/cip1), er, pr, p53, rb, pcna, ki-67, endometrial lesions, kinase inhibitor p21, prognostic-significance, p53-independent expression, proliferative activity, estrogen-receptor, carcinoma, cancer, adenocarcinoma, survival, apoptosis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000186162400008
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής