P21(waf1/cip1) protein expression in normal, hyperplastic and malignant endometrium. Correlation with hormone receptor status, c-erbB-2 oncoprotein, bcl-2 and other cell cycle related proteins (Rb, p53, Ki-67, PCNA)

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dc.contributor.authorIoachim, E.en
dc.contributor.authorKitsiou, E.en
dc.contributor.authorMitselou, A.en
dc.contributor.authorZagorianakou, N.en
dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorSalmas, M.en
dc.contributor.authorMakrydimas, G.en
dc.contributor.authorVougiouklakis, T.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:00:20Z
dc.date.available2015-11-24T19:00:20Z
dc.identifier.issn0204-3564-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19512
dc.rightsDefault Licence-
dc.subjectp21 (waf1/cip1)en
dc.subjecteren
dc.subjectpren
dc.subjectp53en
dc.subjectrben
dc.subjectpcnaen
dc.subjectki-67en
dc.subjectendometrial lesionsen
dc.subjectkinase inhibitor p21en
dc.subjectprognostic-significanceen
dc.subjectp53-independent expressionen
dc.subjectproliferative activityen
dc.subjectestrogen-receptoren
dc.subjectcarcinomaen
dc.subjectcanceren
dc.subjectadenocarcinomaen
dc.subjectsurvivalen
dc.subjectapoptosisen
dc.titleP21(waf1/cip1) protein expression in normal, hyperplastic and malignant endometrium. Correlation with hormone receptor status, c-erbB-2 oncoprotein, bcl-2 and other cell cycle related proteins (Rb, p53, Ki-67, PCNA)en
heal.abstractDefects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumor progression. p21(waf1/cip1) is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21 (waf1/cip1) expression has been investigated, immunohistochemically in a series of 115 endometrial carcinomas, 62 cases of endometrial hyperplasias, and 62 cases of normal endometium. (33 in proliferative phase and 29 in secretoty). The association between p21(waf1/cip1) expression with hormone receptor status, c-erbB-2 and other cell cycle, related proteins p53, Rb, Ki-67, PCNA) was assessed by univariate analysis. Nuclear p21 (waf1/cip1) expression was statistically higher in the group of carcinomas compared with normal proliferative (p=0.005) and secretory (p=0.0012) endometrium. In addition, this expression was higher in hyperplastic lesions compared with normal proliferative (p=0.02) and secretory (p=0.04) endometrium. A statistically significant positive relationship of p21(waf1/cip1) expression with progesterone receptor status (p=0.007), p53 protein (p=0.001), pRb (p<0.0001) and the two proliferative associated indices Ki-67 and PCNA (p<0.0001) was observed. These data indicate that the expression of p21 (waf1/cip1) protein seems to be an early event in endometrial carcinogenesis and is strongly associated with other cell cycle related proteins.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000186162400008-
heal.journalNameExp Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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