A convenient and rapid method for the selective oxygen-17 enrichment of aspartyl peptides during solid-phase synthesis
| dc.contributor.author | Theodorou-Kassioumis, V. | en |
| dc.contributor.author | Biris, N. | en |
| dc.contributor.author | Sakarellos, C. | en |
| dc.contributor.author | Tsikaris, V. | en |
| dc.date.accessioned | 2015-11-24T16:53:38Z | |
| dc.date.available | 2015-11-24T16:53:38Z | |
| dc.identifier.issn | 0040-4039 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/10046 | |
| dc.rights | Default Licence | - |
| dc.subject | isotopic enrichment | en |
| dc.subject | oxygen-17 | en |
| dc.subject | o-17 nmr | en |
| dc.subject | aspartic acid | en |
| dc.subject | rgd peptides | en |
| dc.subject | solid-phase o-17 peptide enrichment | en |
| dc.subject | o-17-nmr | en |
| dc.title | A convenient and rapid method for the selective oxygen-17 enrichment of aspartyl peptides during solid-phase synthesis | en |
| heal.abstract | In this work we describe, for the first time, a rapid and efficient method for O-17 selective labeling on the beta -carboxyl group of an aspartic acid residue already incorporated into a peptide sequence anchored on a solid-phase support. The beta -O-benzyl ester of the Asp residue of the Ac-RGD-benzydrylamine resin was successfully saponified using (NaOH)-O-17 in a methanol/ dichloromethane mixture. The O-17 selective enriched peptide was then released from the solid support by acidic cleavage. The O-17 NMR spectrum confirmed the O-17 labeling of the Asp beta -carboxylate. (C) 2001 Elsevier Science Ltd. All rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | Doi 10.1016/S0040-4039(01)01632-X | - |
| heal.identifier.secondary | <Go to ISI>://000171556600042 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S004040390101632X/1-s2.0-S004040390101632X-main.pdf?_tid=74b29c30-3574-11e3-90ed-00000aab0f02&acdnat=1381826184_2f2f4259b5592d92ea527a7e8f4bea5f | - |
| heal.journalName | Tetrahedron Lett | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2001 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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