How valuable is measurement of peripheral blood natural killer cells at the time of abortion?
Φόρτωση...
Ημερομηνία
Συγγραφείς
Paparistidis, N.
Papadopoulou, C.
Chioti, A.
Papaioannou, D.
Tsekoura, C.
Keramitsoglou, T.
Kontopoulou-Antonopoulou, V.
Agapitos, E.
Balafoutas, C.
Varla-Leftherioti, M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Am J Reprod Immunol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
PROBLEM: Increased peripheral blood natural killer (NK) cells are associated to immune-mediated abortion, but their diagnostic value when measured at the time of miscarriage is unknown. METHOD OF STUDY: In women with therapeutic (A = 79) or elective (C = 34) pregnancy termination, the NK-cell percentage was measured before and 5 days after curettage. Additionally, immune-mediated lesions (scored 0-3) and CD56(+) and CD16(+) decidual NKs (scored 1-3) were detected on the abortion material. RESULTS: Aborters differed from controls in histological scores (P = 0.000) and in NK percentage (>12%) only in the measurement 5 days after the operation (P = 0.038). In comparison to histological lesions, NK measurement was found to have sensitivity 70%, specificity 73.68%, positive prognostic value 89.39% and negative prognostic value 43.75%. CONCLUSION: An Increased NK-cell percentage 5 days after the pregnancy termination could be a marker of immune aetiology of miscarriage, as the probability of an aborter with NK >12% to have an immune-mediated abortion is almost 90%.
Περιγραφή
Λέξεις-κλειδιά
Abortion, Missed/*blood/diagnosis/*immunology/pathology, Adult, Antibodies, Monoclonal/immunology, Antigens, CD56/analysis, Chorionic Villi/immunology/pathology, Female, Humans, Immunohistochemistry, Keratins/analysis/immunology, Killer Cells, Natural/*cytology/*immunology, Lymphocyte Count, Predictive Value of Tests, Receptors, IgG/analysis, Time Factors
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18294356
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0897.2007.00547.x/asset/j.1600-0897.2007.00547.x.pdf?v=1&t=h0aunsff&s=98cc9a2f6fad963b6daca8fea0ad598e36008190
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0897.2007.00547.x/asset/j.1600-0897.2007.00547.x.pdf?v=1&t=h0aunsff&s=98cc9a2f6fad963b6daca8fea0ad598e36008190
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής