How valuable is measurement of peripheral blood natural killer cells at the time of abortion?

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dc.contributor.authorPaparistidis, N.en
dc.contributor.authorPapadopoulou, C.en
dc.contributor.authorChioti, A.en
dc.contributor.authorPapaioannou, D.en
dc.contributor.authorTsekoura, C.en
dc.contributor.authorKeramitsoglou, T.en
dc.contributor.authorKontopoulou-Antonopoulou, V.en
dc.contributor.authorAgapitos, E.en
dc.contributor.authorBalafoutas, C.en
dc.contributor.authorVarla-Leftherioti, M.en
dc.date.accessioned2015-11-24T19:13:05Z
dc.date.available2015-11-24T19:13:05Z
dc.identifier.issn1046-7408-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21152
dc.rightsDefault Licence-
dc.subjectAbortion, Missed/*blood/diagnosis/*immunology/pathologyen
dc.subjectAdulten
dc.subjectAntibodies, Monoclonal/immunologyen
dc.subjectAntigens, CD56/analysisen
dc.subjectChorionic Villi/immunology/pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectKeratins/analysis/immunologyen
dc.subjectKiller Cells, Natural/*cytology/*immunologyen
dc.subjectLymphocyte Counten
dc.subjectPredictive Value of Testsen
dc.subjectReceptors, IgG/analysisen
dc.subjectTime Factorsen
dc.titleHow valuable is measurement of peripheral blood natural killer cells at the time of abortion?en
heal.abstractPROBLEM: Increased peripheral blood natural killer (NK) cells are associated to immune-mediated abortion, but their diagnostic value when measured at the time of miscarriage is unknown. METHOD OF STUDY: In women with therapeutic (A = 79) or elective (C = 34) pregnancy termination, the NK-cell percentage was measured before and 5 days after curettage. Additionally, immune-mediated lesions (scored 0-3) and CD56(+) and CD16(+) decidual NKs (scored 1-3) were detected on the abortion material. RESULTS: Aborters differed from controls in histological scores (P = 0.000) and in NK percentage (>12%) only in the measurement 5 days after the operation (P = 0.038). In comparison to histological lesions, NK measurement was found to have sensitivity 70%, specificity 73.68%, positive prognostic value 89.39% and negative prognostic value 43.75%. CONCLUSION: An Increased NK-cell percentage 5 days after the pregnancy termination could be a marker of immune aetiology of miscarriage, as the probability of an aborter with NK >12% to have an immune-mediated abortion is almost 90%.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1600-0897.2007.00547.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18294356-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1600-0897.2007.00547.x/asset/j.1600-0897.2007.00547.x.pdf?v=1&t=h0aunsff&s=98cc9a2f6fad963b6daca8fea0ad598e36008190-
heal.journalNameAm J Reprod Immunolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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