Hepatitis B surface antigen variant with multiple mutations in the a determinant in an agammaglobulinemic patient
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Authors
Alexopoulou, A.
Baltayiannis, G.
Jammeh, S.
Waters, J.
Dourakis, S. P.
Karayiannis, P.
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peer-reviewed
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J Clin Microbiol
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A patient with agammaglobulinemia developed acute hepatitis that progressed to chronic liver disease with high levels of hepatitis B virus (HBV) DNA in the absence of detectable HBsAg. Sequencing of the a determinant region of HBsAg revealed multiple amino acid substitutions that, unusually, also included a substitution at position 122 that defines subtype specificity. All of these mutations had a profound effect on the antigenicity of this region, which led to the complete failure of variant detection by commercially available routine diagnostic assays or laboratory-based monoclonal antibody assays.
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Keywords
Agammaglobulinemia/*virology, Antibodies, Monoclonal/immunology, Base Sequence, Hepatitis B Antibodies/blood, Hepatitis B Surface Antigens/chemistry/*genetics/immunology, Hepatitis B virus/classification/genetics, Humans, Male, Middle Aged, Molecular Sequence Data, *Mutation, Sequence Analysis, DNA
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http://www.ncbi.nlm.nih.gov/pubmed/15184493
http://jcm.asm.org/content/42/6/2861.full.pdf
http://jcm.asm.org/content/42/6/2861.full.pdf
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής