Hepatitis B surface antigen variant with multiple mutations in the a determinant in an agammaglobulinemic patient

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dc.contributor.authorAlexopoulou, A.en
dc.contributor.authorBaltayiannis, G.en
dc.contributor.authorJammeh, S.en
dc.contributor.authorWaters, J.en
dc.contributor.authorDourakis, S. P.en
dc.contributor.authorKarayiannis, P.en
dc.date.accessioned2015-11-24T19:14:08Z
dc.date.available2015-11-24T19:14:08Z
dc.identifier.issn0095-1137-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21263
dc.rightsDefault Licence-
dc.subjectAgammaglobulinemia/*virologyen
dc.subjectAntibodies, Monoclonal/immunologyen
dc.subjectBase Sequenceen
dc.subjectHepatitis B Antibodies/blooden
dc.subjectHepatitis B Surface Antigens/chemistry/*genetics/immunologyen
dc.subjectHepatitis B virus/classification/geneticsen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMolecular Sequence Dataen
dc.subject*Mutationen
dc.subjectSequence Analysis, DNAen
dc.titleHepatitis B surface antigen variant with multiple mutations in the a determinant in an agammaglobulinemic patienten
heal.abstractA patient with agammaglobulinemia developed acute hepatitis that progressed to chronic liver disease with high levels of hepatitis B virus (HBV) DNA in the absence of detectable HBsAg. Sequencing of the a determinant region of HBsAg revealed multiple amino acid substitutions that, unusually, also included a substitution at position 122 that defines subtype specificity. All of these mutations had a profound effect on the antigenicity of this region, which led to the complete failure of variant detection by commercially available routine diagnostic assays or laboratory-based monoclonal antibody assays.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1128/JCM.42.6.2861-2865.2004-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15184493-
heal.identifier.secondaryhttp://jcm.asm.org/content/42/6/2861.full.pdf-
heal.journalNameJ Clin Microbiolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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