Microvascular repair with 1-mm polytetrafluoroethylene (PTFE) grafts: effect of recombinant tissue-type plasminogen activator (rt-PA) on the patency rate and healing process
| dc.contributor.author | Lykoudis, E. G. | en |
| dc.contributor.author | Papalois, A. E. | en |
| dc.contributor.author | Gravvanis, A. I. | en |
| dc.contributor.author | Frangia, K. B. | en |
| dc.contributor.author | Stamatopoulos, C. N. | en |
| dc.contributor.author | Ioannovich, J. D. | en |
| dc.date.accessioned | 2015-11-24T19:04:22Z | |
| dc.date.available | 2015-11-24T19:04:22Z | |
| dc.identifier.issn | 0738-1085 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20027 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | *Blood Vessel Prosthesis | en |
| dc.subject | Male | en |
| dc.subject | *Microsurgery | en |
| dc.subject | *Polytetrafluoroethylene | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Recombinant Proteins/*pharmacology | en |
| dc.subject | Tissue Plasminogen Activator/*pharmacology | en |
| dc.subject | Vascular Patency/*drug effects | en |
| dc.subject | Vascular Surgical Procedures | en |
| dc.subject | Wound Healing/*drug effects | en |
| dc.title | Microvascular repair with 1-mm polytetrafluoroethylene (PTFE) grafts: effect of recombinant tissue-type plasminogen activator (rt-PA) on the patency rate and healing process | en |
| heal.abstract | The present study assesses the effect of recombinant tissue-type plasminogen activator (rt-PA) on the patency rate and healing process of microvascular polytetrafluoroethylene (PTFE) grafts. Wistar rats were used, divided into four groups of 25 animals each. After dissection of the carotid artery a segment of the vessel, 1 cm long, was resected and replaced by equal length graft. Two different type fibril length (30- or 60-microm) grafts of the same wall thickness (0.18 mm) were used. Normal saline or 3 mg/kg of body weight of rt-PA was applied locally in each group of different fibril length grafts. Patency tests were performed at 15 min and 4 weeks after blood flow was reestablished. All grafts were harvested and examined histologically. The results showed that local application of rt-PA improves patency statistically significantly in both types of fibril length grafts. Patency in 60-microm fibril length grafts was statistically significantly higher than that of 30-microm fibril length grafts, whether rt-PA was used or not. The use of rt-PA had no influence on the healing process of either type of graft. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11119287 | - |
| heal.journalName | Microsurgery | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2000 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: