Significance of conventional and new prognostic factors for locally confined renal cell carcinoma
Φόρτωση...
Ημερομηνία
Συγγραφείς
Hofmockel, G.
Tsatalpas, P.
Muller, H.
Dammrich, J.
Poot, M.
Maurer-Schultze, B.
Muller-Hermelink, H. K.
Frohmuller, H. G.
Bassukas, I. D.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Cancer
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: The prognosis of patients with locally confined renal cell carcinoma is variable. To improve the prognostic knowledge and select patients at high risk, additional prognostic parameters are needed. METHODS: The significance with respect to survival and tumor recurrence of "classic" and "new" prognostic parameters has been examined by following 41 patients with locally confined renal cell carcinoma after nephrectomy (mean follow-up, 5.2 years). The significance of histologic grade, tumor stage, Ki-67 index, proliferating cell nuclear antigen index, 3H-thymidine labeling index, tumor ploidy status, and tumor growth after xenotransplantation into nude mice (GAX range) was tested using the Kaplan-Meier plots by the log rank test or Tarone's test and also by the Cox multiple hazard regression analysis. RESULTS: Tumor stage (P < 0.0025), histologic grade (P < 0.005), Ki-67 index (P < 0.006), and GAX range (P < 0.00004) were found to be significant prognostic parameters for survival and tumor recurrence using single-factor analysis. Applying the multivariate analysis, the combination of the "new" factors, GAX range and Ki-67 index, resulted in even a higher prognostic relevance than the combination of the "classic" prognostic factors, tumor stage and histologic grade. The calculated prognostic index based on the results of the Cox analysis, which, except for stage and grade, included the Ki-67 index, was shown to be highly correlated with survival (P = 0.00002) and tumor recurrence (P = 0.0004). Its prognostic validity was studied with the receiver operating characteristics procedure and was found to be considerably superior to that of the two conventional prognosticators. CONCLUSIONS: The additional determination of the Ki-67 labeling index increases the prognostic assessment of patients with locally confined renal cell carcinoma.
Περιγραφή
Λέξεις-κλειδιά
Animals, Carcinoma, Renal Cell/*diagnosis/pathology, Cell Division, DNA, Neoplasm/analysis, Disease-Free Survival, Female, Ki-67 Antigen, Kidney Neoplasms/*diagnosis/pathology, Male, Mice, Mice, Inbred BALB C, Mice, Nude, Multivariate Analysis, Neoplasm Proteins/metabolism, Neoplasm Transplantation, Nuclear Proteins/metabolism, Prognosis, Proliferating Cell Nuclear Antigen/metabolism, Proportional Hazards Models, Survival Analysis, Transplantation, Heterologous, Tumor Markers, Biological/analysis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/8625106
http://onlinelibrary.wiley.com/store/10.1002/1097-0142(19950715)76:2<296::AID-CNCR2820760221>3.0.CO;2-L/asset/2820760221_ftp.pdf?v=1&t=h0oz3v0c&s=aab81c4fd9a249731685943c7135e04df59253cc
http://onlinelibrary.wiley.com/store/10.1002/1097-0142(19950715)76:2<296::AID-CNCR2820760221>3.0.CO;2-L/asset/2820760221_ftp.pdf?v=1&t=h0oz3v0c&s=aab81c4fd9a249731685943c7135e04df59253cc
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής