Significance of conventional and new prognostic factors for locally confined renal cell carcinoma

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dc.contributor.authorHofmockel, G.en
dc.contributor.authorTsatalpas, P.en
dc.contributor.authorMuller, H.en
dc.contributor.authorDammrich, J.en
dc.contributor.authorPoot, M.en
dc.contributor.authorMaurer-Schultze, B.en
dc.contributor.authorMuller-Hermelink, H. K.en
dc.contributor.authorFrohmuller, H. G.en
dc.contributor.authorBassukas, I. D.en
dc.date.accessioned2015-11-24T18:51:35Z
dc.date.available2015-11-24T18:51:35Z
dc.identifier.issn0008-543X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18280
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectCarcinoma, Renal Cell/*diagnosis/pathologyen
dc.subjectCell Divisionen
dc.subjectDNA, Neoplasm/analysisen
dc.subjectDisease-Free Survivalen
dc.subjectFemaleen
dc.subjectKi-67 Antigenen
dc.subjectKidney Neoplasms/*diagnosis/pathologyen
dc.subjectMaleen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectMice, Nudeen
dc.subjectMultivariate Analysisen
dc.subjectNeoplasm Proteins/metabolismen
dc.subjectNeoplasm Transplantationen
dc.subjectNuclear Proteins/metabolismen
dc.subjectPrognosisen
dc.subjectProliferating Cell Nuclear Antigen/metabolismen
dc.subjectProportional Hazards Modelsen
dc.subjectSurvival Analysisen
dc.subjectTransplantation, Heterologousen
dc.subjectTumor Markers, Biological/analysisen
dc.titleSignificance of conventional and new prognostic factors for locally confined renal cell carcinomaen
heal.abstractBACKGROUND: The prognosis of patients with locally confined renal cell carcinoma is variable. To improve the prognostic knowledge and select patients at high risk, additional prognostic parameters are needed. METHODS: The significance with respect to survival and tumor recurrence of "classic" and "new" prognostic parameters has been examined by following 41 patients with locally confined renal cell carcinoma after nephrectomy (mean follow-up, 5.2 years). The significance of histologic grade, tumor stage, Ki-67 index, proliferating cell nuclear antigen index, 3H-thymidine labeling index, tumor ploidy status, and tumor growth after xenotransplantation into nude mice (GAX range) was tested using the Kaplan-Meier plots by the log rank test or Tarone's test and also by the Cox multiple hazard regression analysis. RESULTS: Tumor stage (P < 0.0025), histologic grade (P < 0.005), Ki-67 index (P < 0.006), and GAX range (P < 0.00004) were found to be significant prognostic parameters for survival and tumor recurrence using single-factor analysis. Applying the multivariate analysis, the combination of the "new" factors, GAX range and Ki-67 index, resulted in even a higher prognostic relevance than the combination of the "classic" prognostic factors, tumor stage and histologic grade. The calculated prognostic index based on the results of the Cox analysis, which, except for stage and grade, included the Ki-67 index, was shown to be highly correlated with survival (P = 0.00002) and tumor recurrence (P = 0.0004). Its prognostic validity was studied with the receiver operating characteristics procedure and was found to be considerably superior to that of the two conventional prognosticators. CONCLUSIONS: The additional determination of the Ki-67 labeling index increases the prognostic assessment of patients with locally confined renal cell carcinoma.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8625106-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/1097-0142(19950715)76:2<296::AID-CNCR2820760221>3.0.CO;2-L/asset/2820760221_ftp.pdf?v=1&t=h0oz3v0c&s=aab81c4fd9a249731685943c7135e04df59253cc-
heal.journalNameCanceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1995-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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