Prefabrication of an axial bio-synthetic flap for circumferential tracheal defect reconstruction
Φόρτωση...
Ημερομηνία
Συγγραφείς
Lykoudis, E. G.
Tsoutsos, D. A.
Papalois, A. E.
Frangia, K. B.
Stamatopoulos, C. N.
Ioannovich, J. D.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Br J Plast Surg
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The aim of this study was to prefabricate an axial bio-synthetic flap for reconstruction of circumferential tracheal defects in a rabbit model. Two series of experiments were performed. In the first set of experiments axial island bio-synthetic flaps were prefabricated. These consisted of an inner island de-epithelialised fasciocutaneous flap from a rabbit's ear and an outer polytetrafluoroethylene vascular graft. The flaps were buried at the base of the rabbit's ear for periods of 1, 2 and 3 weeks (groups A, B and C, respectively), 10 flaps per group. Only one flap in group C failed to survive. Clinical and histological assessment, at the completion of each time period, showed that only the viable flaps of group C developed all the characteristics needed for a tracheal substitute. In the second set of experiments the prefabricated bio-synthetic flaps were transferred to the rabbit's neck by means of microvascular anastomoses. Ten such free flaps were buried at the rabbit's neck for 3 weeks (group D). Eight of the flaps remained viable and all the viable flaps had characteristics similar to those of group C. These results demonstrate the feasibility of creating a prefabricated axial bio-synthetic flap (island or free), over a 3-week period, possessing the characteristics needed for a tracheal substitute in a rabbit model.
Περιγραφή
Λέξεις-κλειδιά
Animals, *Bioprosthesis, Male, Polytetrafluoroethylene/therapeutic use, Rabbits, Reconstructive Surgical Procedures/*methods, *Surgical Flaps, Time Factors, Tissue Survival, Tracheal Diseases/*surgery
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/10927683
http://ac.els-cdn.com/S0007122600933824/1-s2.0-S0007122600933824-main.pdf?_tid=fc3dd0d1d72a853e5b8d30da3f9695dd&acdnat=1333466375_2f3023795d4d7eeb82f32bf3bc2883af
http://ac.els-cdn.com/S0007122600933824/1-s2.0-S0007122600933824-main.pdf?_tid=fc3dd0d1d72a853e5b8d30da3f9695dd&acdnat=1333466375_2f3023795d4d7eeb82f32bf3bc2883af
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής