Testosterone deficiency in young women with 46,XX spontaneous premature ovarian failure
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kalantaridou, S. N.
Calis, K. A.
Vanderhoof, V. H.
Bakalov, V. K.
Corrigan, E. C.
Troendle, J. F.
Nelson, L. M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Fertil Steril
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: To determine whether women with 46,XX spontaneous premature ovarian failure have lower serum free-T levels than do control women. DESIGN: Cross-sectional. SETTING: National Institutes of Health Clinical Research Center. PATIENT(S): Women with 46,XX spontaneous premature ovarian failure (n = 130). INTERVENTION(S): Evaluation while off any estrogen therapy and then again after receiving a standardized hormone regimen. Regularly menstruating control women (n = 65) were sampled during the midfollicular phase. MAIN OUTCOME MEASURE(S): Serum total T by RIA after extraction and column chromatography, free T by equilibrium dialysis, and sex hormone-binding globulin by immunoradiometric assay. RESULT(S): While off estrogen therapy patients had a median serum free-T concentration that was statistically significantly lower than controls (2.2 vs. 3.3 pg/mL). This dropped significantly lower to 1.9 pg/mL while the patients were on physiologic transdermal E(2) therapy. This is despite the fact that sex hormone-binding globulin levels did not change. While on E(2) therapy, 13% of women (95% confidence interval, 7.9%-20.3%) had serum free-T levels below the lower limit of normal (<1.1 pg/mL). CONCLUSION(S): As a group, young women with 46,XX spontaneous premature ovarian failure have reduced circulating free-T levels, both during an interval off of estrogen therapy and while on physiologic transdermal E(2) therapy.
Περιγραφή
Λέξεις-κλειδιά
Chromosomes, Human, X/*genetics, Cross-Sectional Studies, Female, Gonadal Dysgenesis, Mixed/*genetics/*metabolism, Humans, Primary Ovarian Insufficiency/*genetics/*metabolism, Testosterone/*blood/*deficiency/genetics
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17070197
http://ac.els-cdn.com/S0015028206015068/1-s2.0-S0015028206015068-main.pdf?_tid=3894804976589310e4eb1b1bfff0f6f4&acdnat=1333463389_b66acc0e83936ed03ddab1391866d50e
http://ac.els-cdn.com/S0015028206015068/1-s2.0-S0015028206015068-main.pdf?_tid=3894804976589310e4eb1b1bfff0f6f4&acdnat=1333463389_b66acc0e83936ed03ddab1391866d50e
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής