Testosterone deficiency in young women with 46,XX spontaneous premature ovarian failure
| dc.contributor.author | Kalantaridou, S. N. | en |
| dc.contributor.author | Calis, K. A. | en |
| dc.contributor.author | Vanderhoof, V. H. | en |
| dc.contributor.author | Bakalov, V. K. | en |
| dc.contributor.author | Corrigan, E. C. | en |
| dc.contributor.author | Troendle, J. F. | en |
| dc.contributor.author | Nelson, L. M. | en |
| dc.date.accessioned | 2015-11-24T19:42:43Z | |
| dc.date.available | 2015-11-24T19:42:43Z | |
| dc.identifier.issn | 1556-5653 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24682 | |
| dc.rights | Default Licence | - |
| dc.subject | Chromosomes, Human, X/*genetics | en |
| dc.subject | Cross-Sectional Studies | en |
| dc.subject | Female | en |
| dc.subject | Gonadal Dysgenesis, Mixed/*genetics/*metabolism | en |
| dc.subject | Humans | en |
| dc.subject | Primary Ovarian Insufficiency/*genetics/*metabolism | en |
| dc.subject | Testosterone/*blood/*deficiency/genetics | en |
| dc.title | Testosterone deficiency in young women with 46,XX spontaneous premature ovarian failure | en |
| heal.abstract | OBJECTIVE: To determine whether women with 46,XX spontaneous premature ovarian failure have lower serum free-T levels than do control women. DESIGN: Cross-sectional. SETTING: National Institutes of Health Clinical Research Center. PATIENT(S): Women with 46,XX spontaneous premature ovarian failure (n = 130). INTERVENTION(S): Evaluation while off any estrogen therapy and then again after receiving a standardized hormone regimen. Regularly menstruating control women (n = 65) were sampled during the midfollicular phase. MAIN OUTCOME MEASURE(S): Serum total T by RIA after extraction and column chromatography, free T by equilibrium dialysis, and sex hormone-binding globulin by immunoradiometric assay. RESULT(S): While off estrogen therapy patients had a median serum free-T concentration that was statistically significantly lower than controls (2.2 vs. 3.3 pg/mL). This dropped significantly lower to 1.9 pg/mL while the patients were on physiologic transdermal E(2) therapy. This is despite the fact that sex hormone-binding globulin levels did not change. While on E(2) therapy, 13% of women (95% confidence interval, 7.9%-20.3%) had serum free-T levels below the lower limit of normal (<1.1 pg/mL). CONCLUSION(S): As a group, young women with 46,XX spontaneous premature ovarian failure have reduced circulating free-T levels, both during an interval off of estrogen therapy and while on physiologic transdermal E(2) therapy. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.fertnstert.2006.04.028 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17070197 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0015028206015068/1-s2.0-S0015028206015068-main.pdf?_tid=3894804976589310e4eb1b1bfff0f6f4&acdnat=1333463389_b66acc0e83936ed03ddab1391866d50e | - |
| heal.journalName | Fertil Steril | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2006 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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