Anticancer and cytotoxic effects of a triorganotin compound with 2-mercapto-nicotinic acid in malignant cell lines and tumor bearing Wistar rats
Φόρτωση...
Ημερομηνία
Συγγραφείς
Verginadis, I. I.
Karkabounas, S.
Simos, Y.
Kontargiris, E.
Hadjikakou, S. K.
Batistatou, A.
Evangelou, A.
Charalabopoulos, K.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Elsevier
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
European Journal of Pharmaceutical Sciences
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Nowadays, investigation for possible therapeutic applications of various metal-based drugs attracts the scientific interest worldwide. The triorganotin compound bis[triphenyltin(IV)](3-carboxy-pyridine-2-thionato) (SnMNA), was tested for its anti-proliferative and antitumor activities. Cytotoxic activity was assessed by Trypan blue and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT). SnMNA exhibited potent cytotoxic effects against leiomyosarcoma cells (LMS) and human breast adenocarcinoma cells (MCF-7), which is 200 times stronger than that of cisplatin. Moreover, SnMNA induced significant apoptosis in LMS and MCF-7 cells characterized by flow cytometry analysis and DNA fragmentation. Acute and chronic toxicity studies on Wistar rats caused kidney and lung toxicity at a single dose of 80 mg/kg Body Weight (BW) or four repeated doses of 8 mg/kg BW once per week. Furthermore, antitumor activity studies on sarcoma bearing Wistar rats revealed that SnMNA complex at four repeated doses of 5.4 mg/kg BW every three days prolonged mean survival time of the animal at 200% and decreased mean tumor growth rate (MTGR) compared to the control group (p < 0.05). It is noteworthy to mention that the 30% (3 out of 10) of the bearing animals were totally cured. These findings indicate that SnMNA might be a promising new antitumor agent. (C) 2010 Elsevier B.V. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
triorganotin, tin complexes, cytotoxicity, apoptosis, anticancer drugs, in-vitro, organotin compound, antitumor-activity, cervical-cancer, structural-characterization, diorganotin(iv) compounds, alkyl series, dimethyl tin, complexes, vivo
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000287616300010
http://ac.els-cdn.com/S092809871000391X/1-s2.0-S092809871000391X-main.pdf?_tid=984ac33c127a1dbce2008d671cd82c5e&acdnat=1333030284_9ab8b2b400cf2bdd817630ea1acce56e
http://ac.els-cdn.com/S092809871000391X/1-s2.0-S092809871000391X-main.pdf?_tid=984ac33c127a1dbce2008d671cd82c5e&acdnat=1333030284_9ab8b2b400cf2bdd817630ea1acce56e
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας