Anticancer and cytotoxic effects of a triorganotin compound with 2-mercapto-nicotinic acid in malignant cell lines and tumor bearing Wistar rats

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dc.contributor.authorVerginadis, I. I.en
dc.contributor.authorKarkabounas, S.en
dc.contributor.authorSimos, Y.en
dc.contributor.authorKontargiris, E.en
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorEvangelou, A.en
dc.contributor.authorCharalabopoulos, K.en
dc.date.accessioned2015-11-24T16:50:53Z
dc.date.available2015-11-24T16:50:53Z
dc.identifier.issn0928-0987-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9655
dc.rightsDefault Licence-
dc.subjecttriorganotinen
dc.subjecttin complexesen
dc.subjectcytotoxicityen
dc.subjectapoptosisen
dc.subjectanticancer drugsen
dc.subjectin-vitroen
dc.subjectorganotin compounden
dc.subjectantitumor-activityen
dc.subjectcervical-canceren
dc.subjectstructural-characterizationen
dc.subjectdiorganotin(iv) compoundsen
dc.subjectalkyl seriesen
dc.subjectdimethyl tinen
dc.subjectcomplexesen
dc.subjectvivoen
dc.titleAnticancer and cytotoxic effects of a triorganotin compound with 2-mercapto-nicotinic acid in malignant cell lines and tumor bearing Wistar ratsen
heal.abstractNowadays, investigation for possible therapeutic applications of various metal-based drugs attracts the scientific interest worldwide. The triorganotin compound bis[triphenyltin(IV)](3-carboxy-pyridine-2-thionato) (SnMNA), was tested for its anti-proliferative and antitumor activities. Cytotoxic activity was assessed by Trypan blue and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT). SnMNA exhibited potent cytotoxic effects against leiomyosarcoma cells (LMS) and human breast adenocarcinoma cells (MCF-7), which is 200 times stronger than that of cisplatin. Moreover, SnMNA induced significant apoptosis in LMS and MCF-7 cells characterized by flow cytometry analysis and DNA fragmentation. Acute and chronic toxicity studies on Wistar rats caused kidney and lung toxicity at a single dose of 80 mg/kg Body Weight (BW) or four repeated doses of 8 mg/kg BW once per week. Furthermore, antitumor activity studies on sarcoma bearing Wistar rats revealed that SnMNA complex at four repeated doses of 5.4 mg/kg BW every three days prolonged mean survival time of the animal at 200% and decreased mean tumor growth rate (MTGR) compared to the control group (p < 0.05). It is noteworthy to mention that the 30% (3 out of 10) of the bearing animals were totally cured. These findings indicate that SnMNA might be a promising new antitumor agent. (C) 2010 Elsevier B.V. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.ejps.2010.11.015-
heal.identifier.secondary<Go to ISI>://000287616300010-
heal.identifier.secondaryhttp://ac.els-cdn.com/S092809871000391X/1-s2.0-S092809871000391X-main.pdf?_tid=984ac33c127a1dbce2008d671cd82c5e&acdnat=1333030284_9ab8b2b400cf2bdd817630ea1acce56e-
heal.journalNameEuropean Journal of Pharmaceutical Sciencesen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2011-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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